This page highlights the top published articles in the field of cardiology, electrophysiology, and digital health.

Electrophysiology:

Long-Term Outcomes of Resynchronization–Defibrillation for Heart Failure

Stroke risk in women with atrial fibrillation.

Arrhythmic Risk in Biventricular Pacing Compared with Left Bundle Branch Area Pacing: Results From the I-CLAS Study

Sex-Specific Outcomes of LBBAP Versus Biventricular Pacing: Results From I-CLAS

Outcomes of Upgrading to LBBP in CRT Nonresponders: A Prospective, Multicenter, Nonrandomized, Case-Control Study

In Vivo Base Editing of Scn5a Rescues Type 3 Long QT Syndrome in Mice

Update on Cardiovascular Implantable Electronic Device Infections and Their Prevention, Diagnosis, and Management: A Scientific Statement from the American Heart Association

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Sudden Cardiac Death in Young Athletes: JACC State-of-the-Art Review

Antithrombotic Therapy for Patients Undergoing Cardiac Electrophysiological and Interventional Procedures: JACC State-of-the-Art Review

Ablation for atrial fibrillation improves the outcomes in patients with heart failure with preserved ejection fraction.

Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy

Redo procedures after sinus node sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia.

Electrophysiological characteristics and ablation of ventricular arrhythmias originating from the intramural basal inferior septum.

Effects of Contact Force on Lesion Size During Pulsed Field Catheter Ablation: Histochemical Characterization of Ventricular Lesion Boundaries

Clinical Management of Brugada Syndrome: Commentary From the Experts

Triggers of Ventricular Fibrillation in Patients With Inferolateral J-Wave Syndrome

QRS Morphology and the Risk of Ventricular Tachyarrhythmia in Cardiac Resynchronization Therapy Recipients

Bilateral Cardiac Sympathetic Denervation for Refractory Multifocal Premature Ventricular Contractions in Patients With Nonischemic Cardiomyopathy

A novel automated peak frequency annotation algorithm for identifying deceleration zones and ventricular tachycardia ablation sites.

UltraSOUND-based characterization of ventricular tachycardia SCAR and arrhythmogenic substrate: The SOUNDSCAR study

How to perform cardioneuroablation for vasovagal syncope and functional bradycardia

Advances in understanding of cardiac sodium channel structure/function and their relation to disease pathogenesis and treatment

Cardiology:

Impact of a clinician-to-clinician electronic consultation in heart failure patients with previous hospital admissions

Peripartum Cardiomyopathy

Treatment of severe symptomatic aortic valve stenosis using non-invasive ultrasound therapy: a cohort study

Dapagliflozin and Mode of Death in Heart Failure with Improved Ejection Fraction. A Post Hoc Analysis of the DELIVER Trial

Residual leaks following percutaneous left atrial appendage occlusion and outcomes: a meta-analysis.

Platelet biology and function: plaque erosion vs. rupture

2023 American Heart Association Focused Update on Adult Advanced Cardiovascular Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Cardiac Catheterization Laboratory Management of the Comatose Adult Patient with an Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association

Coronary Artery Calcification: Current Concepts and Clinical Implications

Resistance Exercise Training in Individuals With and Without Cardiovascular Disease: 2023 Update: A Scientific Statement From the American Heart Association

High-Sensitivity Cardiac Troponin I Enhances Preeclampsia Prediction Beyond Maternal Factors and the sFlt-1/PlGF Ratio

Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society

Lipoprotein(a) Is Markedly More Atherogenic Than LDL: An Apolipoprotein B-Based Genetic Analysis

Comparison of Direct Oral Anticoagulants vs Vitamin K Antagonists After Transcatheter Mitral Valve Replacement

Artificial Intelligence:

Artificial intelligence in detecting left atrial appendage thrombus by transthoracic echocardiography and clinical features: the Left Atrial Thrombus on Transesophageal Echocardiography (LATTEE) registry

Wearable Digital Health Technologies for Monitoring in Cardiovascular Medicine

Improving cardiovascular risk prediction through machine learning modelling of irregularly repeated electronic health records 

Machine learning-derived cycle length variability metrics predict spontaneously terminating ventricular tachycardia in implantable cardioverter defibrillator recipients

Automatic triage of twelve-lead electrocardiograms using deep convolutional neural networks: a first implementation study

Electrophysiology:

Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial

ECG deep learning for predicting post-procedural mortality: a model development and validation study

Prevalence and incidence of diastolic dysfunction in atrial fibrillation: clinical implications

Acquired risk factors and incident atrial fibrillation according to age and genetic predisposition

Sinus rhythm QRS morphology reflects right ventricular activation and anatomical ventricular tachycardia isthmus conduction in repaired tetralogy of Fallot

Association of epicardial and intramyocardial fat with ventricular arrhythmias

Diagnostic pitfalls in patients referred for arrhythmogenic right ventricular cardiomyopathy

Effects of Synchronizing Foot Strike and Cardiac Phase on Exercise Hemodynamics in Patients with Cardiac Resynchronization Therapy: A Within-Subjects Pilot Study to Fine-Tune Cardio-Locomotor Coupling for Heart Failure

Association of LP(a) Levels with Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis

Assessing left atrial intramyocardial fat infiltration from computerized tomography angiography in patients with atrial fibrillation

Genetic Atrial Cardiomyopathies: Common Features, Specific Differences, and Broader Relevance to Understanding Atrial Cardiomyopathy

Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure

The Prevalence and Characteristics of Arrhythmic Mitral Valve Prolapse in Patients with Unexplained Cardiac Arrest

Utility of Very High-Output Pacing to Identify VT Circuits in Patients Manifesting Traditionally Inexcitable Scar

Posterior Wall Isolation Improves Outcomes for Persistent AF with Rapid Posterior Wall Activity: CAPLA Sub-study

ECG characteristics of “true” left bundle branch block: Insights from transcatheter aortic valve–related LBBB and His-Purkinje conduction system pacing–correctable LBBB

Association between nighttime heart rate and cardiovascular mortality in patients with implantable cardioverter-defibrillator: A cohort study

Restoration of calcium release synchrony: A novel target for heart failure and ventricular arrhythmia

Cardiology:

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia

A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomized placebo-controlled trial

Variants at the Interleukin 1 Gene Locus and Pericarditis

Mechanisms of enhanced renal and hepatic erythropoietin synthesis by sodium–glucose cotransporter 2 inhibitors

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

Role of Advanced Practice Providers in the Cardiac Intensive Care Unit Team

Comparison of Intravascular Imaging, Functional, or Angiographically Guided Coronary Intervention

Electrophysiology:

Fatal Cardiac Arrhythmias during Electronic Gaming in Patients with Genetically Mediated Heart Diseases

Return-to-Play for Elite Athletes with Genetic Heart Diseases Predisposing to Sudden Cardiac Death

Risk of Arrhythmic Death in Patients with Non-ischemic Cardiomyopathy: JACC Review

Autoimmune Atrial Fibrillation

Ventricular Electrograms Duration Map to Detect Ventricular Arrhythmia Substrate: the VEDUM Project Study

Dronedarone Versus Sotalol in Antiarrhythmic Drug–Naive Veterans With Atrial Fibrillation

Lipomatous Metaplasia Facilitates Slow Conduction in Critical Ventricular Tachycardia Corridors within postinfarct Myocardium

Conduction Velocity Dispersion Predicts Postinfarct Ventricular Tachycardia Circuit Sites and Associates With Lipomatous Metaplasia

Reappraisal and New Observations on Idiopathic Ventricular Arrhythmias Ablated From the Noncoronary Aortic Sinus

Mitral Annular Substrate and Ventricular Arrhythmias in Arrhythmogenic Mitral Valve Prolapse with Mitral Annular Disjunction

Arrhythmic Mitral Valve Prolapse With Only Mild or Moderate Mitral Regurgitation: Characterization of Myocardial Substrate

Long-Term Outcome of Cardiac Denervation Procedures: The Anatomically Guided Septal Approach

Pulmonary Artery Denervation Inhibits Left Stellate Ganglion Stimulation-Induced Ventricular Arrhythmias Originating From the RVOT

A Novel ECG-Based Deep Learning Algorithm to Predict Cardiomyopathy in Patients with Premature Ventricular Complexes

Epicardial Roof-Dependent Macro–Re-Entrant Tachycardia after Ablation of Atrial Fibrillation: Electrophysiological Characteristics and Ablation

Utility and Limitations of Ablation Index for Guiding Therapy in Ventricular Myocardium

Substrate Imaging Before Catheter Ablation of Ventricular Tachycardia: Risk Prediction for Acute Hemodynamic Decompensation

Association of Sinus Wavefront Activation and Ventricular Extrastimuli Mapping with Ventricular Tachycardia Re-Entrant Circuits

Catheter ablation of ventricular premature depolarizations originating from the mid interventricular septum: Significance of electrocardiographic morphology for predicting origin

Improved outcomes of conduction system pacing in heart failure with reduced ejection fraction: A systematic review and meta-analysis

Polygenic risk scores are associated with atrial electrophysiologic substrate abnormalities and outcomes after atrial fibrillation catheter ablation

Cardiology:

Artificial intelligence-based model to classify cardiac functions from chest radiographs: a multi-institutional, retrospective model development and validation study

Cardiac Remodeling in Subclinical Hypertrophic Cardiomyopathy: The VANISH Trial

Modification of the GRACE Risk Score for Risk Prediction in Patients with Acute Coronary Syndromes

Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond

Coronary steal: how many thieves are out there?

Novel therapy for ischemia with no obstructive coronary arteries

Stroke in patients with heart failure and reduced or preserved ejection fraction

Personalized antiplatelet therapies for coronary artery disease: what the future holds

Considerations on the Management of Acute Postoperative Ischemia after Cardiac Surgery: A Scientific Statement from the American Heart Association

Right Ventricular Function and Pulmonary Coupling in Patients with Heart Failure and Preserved Ejection Fraction

Management of Worsening Heart Failure with Reduced Ejection Fraction

Electrophysiology:

Use, misuse, and pitfalls of the drug challenge test in the diagnosis of the Brugada syndrome

Pacing or ablation for vasovagal syncope: one size does not fit all

Impact of early vs. delayed atrial fibrillation catheter ablation on atrial arrhythmia recurrences

Short-duration head-up tilt test potentiated with sublingual nitroglycerin in suspected vasovagal syncope: the fast Italian protocol

Safety and Effectiveness of Pulsed Field Ablation to Treat Atrial Fibrillation: One-Year Outcomes from the MANIFEST-PF Registry

Cognitive Behavioral Therapy Improves Quality of Life in Patients with Symptomatic Paroxysmal Atrial Fibrillation

Individualized Family Screening for Arrhythmogenic Right Ventricular Cardiomyopathy

Comparison of Left Bundle Branch Area Pacing and Biventricular Pacing in Candidates for Resynchronization Therapy

Evaluation of a new treadmill exercise protocol to unmask type 1 Brugada electrocardiographic pattern: can we improve diagnostic yield?

Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for nonischemic cardiomyopathy—a nationwide cohort study

Pulsed Field versus Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation: Efficacy, Safety, and Long-Term Follow-Up in a 400-Patient Cohort

Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs with Potential to Prolong Cardiac Repolarization

Mitral Annular Substrate and Ventricular Arrhythmias in Arrhythmogenic Mitral Valve Prolapse with Mitral Annular Disjunction

Post-Shock Asystole in Patients Dying Out of Hospital While Wearing a Cardioverter Defibrillator

Pulmonary Artery Denervation Inhibits Left Stellate Ganglion Stimulation-Induced Ventricular Arrhythmias Originating From the RVOT

Comparison of Pacing Performance and Clinical Outcomes between Left Bundle Branch and His Bundle Pacing

Ventricular Parasystole in Cardiomyopathy Patients: A Link between His-Purkinje System Damage and Ventricular Fibrillation

Cardiology:

Comparative effectiveness of SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas on risk of major adverse cardiovascular events: emulation of a randomized target trial using electronic health records

Moderate-Intensity Statin with Ezetimibe Combination Therapy vs High-Intensity Statin Monotherapy in Patients at Very High Risk of Atherosclerotic Cardiovascular Disease: RACING Randomized Clinical Trial.

Great debate: lipid-lowering therapies should be guided by vascular imaging rather than by circulating biomarkers

Great Debate: Computed tomography coronary angiography should be the initial diagnostic test in suspected angina

Vegetarian or vegan diets and blood lipids: a meta-analysis of randomized trials

Red meat consumption, cardiovascular diseases, and diabetes: a systematic review and meta-analysis

Treatment Strategies for Cardiomyopathy in Children: A Scientific Statement from the American Heart Association

Long-Term Outcomes of Women with Peripartum Cardiomyopathy Having Subsequent Pregnancies

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events

Consumer Wearable Health and Fitness Technology in Cardiovascular Medicine: JACC State-of-the-Art Review

Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State

Cardiac Myosin Inhibitors for Managing Obstructive Hypertrophic Cardiomyopathy:

JACC: Heart Failure State-of-the-Art Review

Management of Heart Failure–Related Cardiogenic Shock: Practical Guidance for Clinicians

Electrophysiology:

Association between Syncope Trigger Type and Risk of Subsequent Life-Threatening Events in Patients with Long QT Syndrome

Direct Oral Anticoagulants versus Warfarin across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses from COMBINE AF

CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling

Effects of Atrial Fibrillation Screening According to N-Terminal Pro-B-Type Natriuretic Peptide: A Secondary Analysis of the Randomized LOOP Study

Multidisciplinary Critical Care Management of Electrical Storm: JACC State-of-the-Art Review

Ventricular Arrhythmias Associated with Over-the-Counter and Recreational Opioids

Pathogenesis, Evaluation, and Management of Pulmonary Vein Stenosis: JACC Review Topic of the Week

Silent cerebral lesions following catheter ablation for atrial fibrillation: a state-of-the-art review

Stepwise application of ECG and electrogram-based criteria to ensure electrical resynchronization with left bundle branch pacing

The R″ wave in V1 and the negative terminal QRS vector in aVF combine to a novel 12-lead ECG algorithm to identify slow conducting anatomical isthmus 3 in patients with tetralogy of Fallot

Cost-effectiveness of an antibacterial envelope for infection prevention in patients undergoing cardiac resynchronization therapy reoperations in Denmark

Identifying the prognostic significance of early arrhythmia recurrence during the blanking period and the optimal blanking period duration: insights from the DECAAF II study

Head-to-Head Comparison of T1 Mapping and Electroanatomical Voltage Mapping in Patients with Ventricular Arrhythmias

Evolution of Deceleration Zones during Ventricular Tachycardia Ablation and Relation with Cardiac Magnetic Resonance

Causes of Early Mortality after Ventricular Tachycardia Ablation in Patients with Reduced Ejection Fraction

Matching Ablation Endpoints to Long-Term Outcome: The Prospective Multicenter Italian Ventricular Tachycardia Ablation Registry

Effects of Atrioventricular Optimization on Left Ventricular Reverse Remodeling With Cardiac Resynchronization Therapy: Results of the SMART-CRT Trial

Stellate ganglion instrumentation for pharmacological blockade, nerve recording, and stimulation in patients with ventricular arrhythmias: Preliminary experience

Sinus rhythm electrocardiographic abnormalities, sites of origin, and ablation outcomes of ventricular premature depolarizations initiating ventricular fibrillation

Vagal response is involved in the occurrence of ventricular fibrillation in patients with early repolarization syndrome

Device–device interaction between cardiac implantable electronic devices and continuous-flow left ventricular assist devices

Catheter and surgical ablation for ventricular tachycardia in patients with left ventricular assist devices

Cardiology:

Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension

Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial

Digitalis in heart failure: declining use and ongoing outcome trials

Hypertension management in patients with cardiovascular comorbidities

Great debate: in patients with decompensated heart failure, acetazolamide in addition to loop diuretics is the first choice

Spatial Transcriptional Mapping Reveals Site-Specific Pathways Underlying Human Atherosclerotic Plaque Rupture

Remote Monitoring for Heart Failure Management at Home: JACC Scientific Statement

Association of Beta-Blocker Therapy with Cardiovascular Outcomes in Patients with Stable Ischemic Heart Disease

How to Manage Heart Failure with Preserved Ejection Fraction: Practical Guidance for Clinicians

The R-wave amplitude in V1 on baseline electrocardiogram correlates with the occurrence of high-degree atrioventricular block following left bundle branch block after trans-catheter aortic valve replacement

Ventricular rate in atrial fibrillation and the risk of heart failure and death

Treatment of pathophysiologic propagation outside of the pulmonary veins in retreatment of atrial fibrillation patients: RECOVER AF study

Efficacy and safety in patients treated with a novel radiofrequency balloon: a two centers experience from the AURORA collaboration

Catheter ablation of atrial fibrillation and atrial tachycardia in patients with pulmonary hypertension: a randomized study

Randomized Trial of Stand-Alone Use of the Antimicrobial Envelope in High-Risk Cardiac Device Patients

Outcomes of Early Rhythm Control Therapy in Patients with Atrial Fibrillation and a High Comorbidity Burden in Large Real-World Cohorts

Novel Approaches for the Diagnosis of Concealed Nodo-Ventricular and His-Ventricular Pathways

Pulmonary Vein Isolation with and Without Posterior Wall Isolation in Paroxysmal Atrial Fibrillation: IMPPROVE-PAF Trial

Left Atrial Appendage Occlusion in the Elderly: Insights from PROTECT-AF, PREVAIL, and Continuous Access Registries

Multipolar Ablation Using Mapping Electrodes: A Novel Approach to Intramural Arrhythmia Substrates

Failure of Intrinsic Antitachycardia Pacing to Terminate Ventricular Tachycardia and Potential Proarrhythmic Effects

Anterior mitral line in patients with persistent atrial fibrillation and anterior scar: A multicenter matched comparison—The MiLine study

Electrocardiographic and electrophysiological characteristics of ventricular arrhythmias from the right bundle branch of the moderator band

Right ventricular cardiac resynchronization therapy in patients with right ventricular conduction delay and heart failure

Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential

Reversal and removal of oral antithrombotic drugs in patients with active or perceived imminent bleeding

Reversal agents for current and forthcoming direct oral anticoagulants

Outcomes of patients with atrial fibrillation and ischemic stroke while on oral anticoagulation

2023 HRS/EHRA/APHRS/LAHRS Expert Consensus Statement on Practical Management of the Remote Device Clinic

Should lethal arrhythmias in hypertrophic cardiomyopathy be predicted using non-electrophysiological methods?

Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study

Evidence for concealed fasciculo-ventricular connections as revealed by His bundle pacing

Time of onset of atrial fibrillation and atrial fibrillation progression data from the RACE V study

Timing of cardiac resynchronization therapy implantation

Dynamic changes in nocturnal heart rate predict short-term cardiovascular events in patients using the wearable cardioverter-defibrillator: from the WEARIT-France cohort study

Electrophysiology:

Impact of Early Versus Delayed Atrial Fibrillation Catheter Ablation on Atrial Arrhythmia Recurrences

A worldwide survey on incidence, management and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study.

EHRA clinical consensus statement on conduction system pacing implantation.

EHRA expert consensus document on the management of arrhythmias in frailty syndrome

Non-coding RNA and arrhythmias: expression, function, and molecular mechanism.

An artificial intelligence–based model for prediction of atrial fibrillation from single-lead sinus rhythm electrocardiograms facilitating screening.

Ambulatory pulmonary vein isolation workflow using the Perclose ProglideTM suture-mediated vascular closure device: the PRO-PVI study.

Mapping-guided atrial lead placement determines optimal conduction across Bachmann’s bundle: a rationale for patient-tailored pacing therapy.

Non-invasive three-dimensional electrical activation mapping to predict cardiac resynchronization therapy response: site of latest left ventricular activation relative to pacing site.

Single beta-blocker or combined amiodarone therapy in implantable cardioverter-defibrillator and cardiac resynchronization therapy—defibrillator patients: Insights from the German DEVICE registry.

New insights into atrioventricular nodal anatomy, physiology, and immunochemistry: A comprehensive review and a proposed model of the slow-fast atrioventricular nodal reentrant tachycardia circuit in agreement with direct potential recordings in the Koch’s triangle area.

New insights into the mechanisms of fast and slow conduction in the atrioventricular node

Bronchial Safety After Pulsed Field Ablation for Paroxysmal Atrial Fibrillation.

An Exercise and Physical Activity Program in Patients with Atrial Fibrillation: The ACTIVE-AF Randomized Controlled Trial.

Pulsed Field Ablation to Treat Atrial Fibrillation: Autonomic Nervous System Effects.

Marked QTc Reduction Immediately Following Direct Current Cardioversion of Atrial Fibrillation: Clinical Implications and Mechanisms.

Risks of Heart Failure, Stroke, and Bleeding in Atrial Fibrillation According to Heart Failure Phenotypes.

Kinase Inhibitors and Atrial Fibrillation: Mechanisms of Action and Clinical Implications.

Cardiology:

Dietary Sodium Restriction in Patients with Heart Failure.

Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension.

Genome editing prevents hypertrophic cardiomyopathy in mice.

Temporary mechanical circulatory support devices: practical considerations for all stakeholders.

Effect of Dapagliflozin on Total Heart Failure Events in Patients with Heart Failure With Mildly Reduced or Preserved Ejection Fraction.

Myocardial Metabolomics of Human Heart Failure with Preserved Ejection Fraction

Transiently achieved very low low-density lipoprotein cholesterol levels by statin and alirocumab after acute coronary syndrome are associated with cardiovascular risk reduction: the ODYSSEY OUTCOMES trial.

Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE.

Overcoming professional barriers encountered by women in interventional cardiology: an EAPCI statement.

Variation in Renal Function Following Transition to Sacubitril/Valsartan in Patients with Heart Failure.

Heart Failure Following Anti-Inflammatory Medications in Patients with Type 2 Diabetes Mellitus.

Artificial Intelligence:

Readiness for implementation of novel digital health interventions for postoperative monitoring: a systematic review and clinical innovation network analysis.

Does deidentification of data from wearable devices give us a false sense of security? A systematic review.

Validation of a novel numerical model to predict regionalized blood flow in the coronary arteries.

Premature atrial and ventricular contractions detected on wearable-format electrocardiograms and prediction of cardiovascular events.

Machine learning in sudden cardiac death risk prediction: a systematic review.

Artificial Intelligence:

How to regulate evolving AI health algorithms

Characterizing cyber harms from digital health

Implementing clinical trial data sharing requires training a new generation of biomedical researchers

A call for deep-learning healthcare

Electrophysiology:

Type 2 DM and higher rate of complete atrioventricular block: a Danish Nationwide Registry

Impact of Low Body Mass Index on Cardiac Tamponade during Catheter Ablation for Atrial Fibrillation

Systemic Delivery of Extracellular Vesicles Attenuates Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction

Initial Findings from the National Cardiovascular Data Registry of Atrial Fibrillation Ablation Procedures

Temporal and Spatial Changes of Proarrhythmic Substrate in Premature Ventricular Contraction–Induced Cardiomyopathy

Left and Right PVC-Induced Ventricular Dysfunction

Effect of Direct Slow Pathway Capture Mapping–Guided Ablation on Typical Atrioventricular Nodal Re-Entrant Tachycardia

The Value of Programmed Ventricular Extrastimuli From the Right Ventricular Basal Septum During Supraventricular Tachycardia

Substrate Mapping Alters Ventricular Tachycardia Inducibility

Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity

Recurrences of Atrial Fibrillation Despite Durable Pulmonary Vein Isolation: The PARTY-PVI Study

Novel Ablation Strategy Targeting the Slow Pathway Visualized by Ultrahigh-Resolution Mapping in Typical Slow-Fast Atrioventricular Nodal Reentrant Tachycardia

Cardiology:

Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation

Intravascular Imaging–Guided or Angiography-Guided Complex PCI

Transcatheter Repair for Patients with Tricuspid Regurgitation

Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

Effectiveness, reach, uptake, and feasibility of digital health interventions for adults with type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials

Effectiveness, reach, uptake, and feasibility of digital health interventions for adults with hypertension: a systematic review and meta-analysis of randomised controlled trials

Performance of the European Society of Cardiology 0/1-Hour Algorithm with High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease

Artificial intelligence to enhance clinical value across the spectrum of cardiovascular healthcare

Comparison Of 3-6 Month Versus 12 Month Dual Antiplatelet Therapy After Coronary Intervention Using the Contemporary Drug-eluting Stents With Ultrathin Struts: The HOST-IDEA Randomized Clinical Trial

Prevalence and Clinical Implications of Tricuspid Valve Prolapse Based on Magnetic Resonance Diagnostic Criteria

Pericoronary Adipose Tissue as a Marker of Cardiovascular Risk: JACC Review Topic of the Week

Electrophysiology:

Retrospective Window of Interest Annotation Provides New Insights into Functional Channels in Ventricular Tachycardia Substrate

Importance of Right Ventricular Mapping and Ablation for Ventricular Tachycardia in Postinfarction Patients

Cardioneuroablation for Reflex Syncope: Efficacy and Effects on Autonomic Cardiac Regulation—A Prospective Randomized Trial

Isoproterenol-Assisted Differentiation between Sludge and Organized Thrombus to Guide Left Atrial Appendage Occlusion

Cardiac Repolarization in Health and Disease: State-Of-The-Art Review

Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care: Post Hoc Analysis of the LOOP Randomized Clinical Trial

Association of Left Atrial Strain with Ischemic Stroke Risk in Older Adults

Genetic variants associated with syncope implicate neural and autonomic processes

Value of screening for the risk of sudden cardiac death in young competitive athletes

Comparative Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin in Patients with Atrial Fibrillation and Chronic Liver Disease: A Nationwide Cohort Study

Combined Minimally Invasive Surgical and Percutaneous Catheter Ablation of Atrial Fibrillation: JACC Review Topic of the Week

Association between Number of Volunteer Responders and Interventions before Ambulance Arrival for Cardiac Arrest

Cardiology:

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

The next generation of evidence-based medicine

Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial

Machine learning for classification of hypertension subtypes using multi-omics: A multi-centre, retrospective, data-driven study

Renal denervation in the management of hypertension in adults.

Immunodeficiency is prevalent in congenital heart disease and associated with increased risk of emergency admissions and death

Rule-out of non-ST-segment elevation acute coronary syndrome by a single, pre-hospital troponin measurement: a randomized trial

Anesthetic Care of the Pregnant Patient with Cardiovascular Disease: A Scientific Statement from the American Heart Association

P2Y12 Inhibitor Monotherapy or Dual Antiplatelet Therapy after Complex Percutaneous Coronary Interventions

Prevalence and Professional Impact of Mental Health Conditions among Cardiologists

Intravascular Imaging during Percutaneous Coronary Intervention: JACC State-of-the-Art Review

Left Ventricular Filling Pressure in Chronic Thromboembolic Pulmonary Hypertension

Bleeding Events after Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review

Approaches to Genetic Screening in Cardiomyopathies: Practical Guidance for Clinicians

Longer-Term Effects of Remote Patient Management Following Hospital Discharge after Acute Systolic Heart Failure: The Randomized E-INH Trial

Cardiopulmonary Exercise Testing With Simultaneous Echocardiography: Blueprints of a Dyspnea Clinic for Suspected HFpEF

Electrophysiology:

Abnormal Conduction Zone Detected by Isochronal Late Activation Mapping Accurately Identifies the Potential Atrial Substrate and Predicts the Atrial Fibrillation Ablation Outcome after Pulmonary Vein Isolation

Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction

Cardiac Resynchronization Therapy Improves Outcomes in Patients with Intraventricular Conduction Delay but Not Right Bundle Branch Block: A Patient-Level Meta-Analysis of Randomized Controlled Trials

Pleomorphic Ventricular Tachycardia in Dilated Cardiomyopathy Predicts Ventricular Tachycardia Recurrence after Ablation Independent from Cardiac Function: Comparison with Patients with Ischemic Heart Disease

Chronic Kidney Disease Induces Proarrhythmic Remodeling

Electrophysiology, Pathology, and Imaging of PFA of Scarred and Healthy Ventricles in Swine

Atrial Endocardial Unipolar Voltage Mapping for Detection of Viable Intramural Myocardium

Premature Atrial Contraction Location and Atrial Fibrillation Inducibility

Cardiology:

Cystatin C–Based Equation to Estimate GFR without the Inclusion of Race and Sex

Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest

Performance of cardiovascular disease risk prediction equations in more than 14 000 survivors of cancer in New Zealand primary care: a validation study

Association of Rurality with Risk of Heart Failure

The year in cardiovascular medicine 2022: the top 10 papers in dyslipidaemias

The year in cardiovascular medicine 2022: the top 10 papers in interventional cardiology

Factor XI inhibitors: cardiovascular perspectives

Acute, periprocedural and long-term antithrombotic therapy in older adults: 2022 Update by the ESC Working Group on Thrombosis

Interleukin-33 Mediates Cardiomyopathy after Acute Kidney Injury by Signaling to Cardiomyocytes

Thromboprophylaxis in Patients With Fontan Circulation

Infective Endocarditis after Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review

Worsening Heart Failure: Nomenclature, Epidemiology, and Future Directions

Electrophysiology:

Regional Antibiotic Delivery for Implanted Cardiovascular Electronic Device Infections

Impact of Left Ventricular Papillary Muscle Ventricular Arrhythmia Ablation on Mitral Valve Function

Effect of Epicardial Pulsed Field Ablation Directly on Coronary Arteries

QT Prolongation and In-Hospital Ventricular Arrhythmic Complications in Patients with Apical Ballooning Takotsubo Syndrome

Safety of Pill-in-the-Pocket Class 1C Antiarrhythmic Drugs for Atrial Fibrillation

Serial 7-Day ECG Patch Screening for AF in High-Risk Older Women by the CHARGE-AF Score

Ventricular Arrhythmias and Implantable Cardioverter-Defibrillator Therapy in Women: A Propensity Score-Matched Analysis

Advances of Implantation Techniques for Conduction System Pacing

Cardiology:

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

Trial of an Intervention to Improve Acute Heart Failure Outcomes

Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events

Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications

Coronary microvascular dysfunction is associated with impaired cognitive function: the Cerebral-Coronary Connection study (C3 study)

Exercise Volume versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings from the MARC-2 Study

Targeting Epsins to Inhibit Fibroblast Growth Factor Signaling While Potentiating Transforming Growth Factor-β Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis

Takayasu Arteritis: JACC Focus Seminar 3/4

Nutritional Heart Disease and Cardiomyopathies: JACC Focus Seminar 4/4

Prediction of Left Ventricular Ejection Fraction Change Following Treatment with Sacubitril/Valsartan

Prediction of LV Reverse Remodeling and Outcomes by Circulating Collagen-Derived Peptides

Cardiology:

Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events

Machine learning-based marker for CAD: derivation and validation in two longitudinal cohorts

Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study

Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention

Valvular heart disease: shifting the focus to the myocardium

Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial

Peptide Vaccine against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia

Survival after Invasive or Conservative Management of Stable Coronary Disease

Comparative Effects of Low-Dose Rosuvastatin, Placebo, and Dietary Supplements on Lipids and Inflammatory Biomarkers

Direct Oral Anticoagulants vs Vitamin K Antagonists in Patients with Antiphospholipid Syndromes: Meta-Analysis of Randomized Trials

Infections and Cardiovascular Disease: JACC Focus Seminar 1/4

Rheumatic Heart Disease: JACC Focus Seminar 2/4

Electrophysiology:

Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST-AFNET 4 trial

Fit for the future: empowering clinical trials with digital technology

Clinical benefits of concomitant surgical ablation for AF in patients undergoing mitral valve surgery

Outcomes in patients with electrocardiographic left ventricular dyssynchrony following transcatheter aortic valve replacement

Differences in mode of death between men and women receiving implantable cardioverter-defibrillators or cardiac resynchronization therapy in the MADIT trials

Left bundle area pacing: Guiding implant depth by ring measurements

Neuromodulation therapy for atrial fibrillation

Characterization of ventricular arrhythmias and sudden cardiac death in subjects with mitral valve prolapse and mitral annular disjunction

Three-dimensional functional anatomy of the human sinoatrial node for epicardial and endocardial mapping and ablation

Outcomes of a PAINESD score–guided multidisciplinary management approach for patients with ventricular tachycardia storm and advanced heart failure

Electrophysiology:

Bleeding and ischemic events after first bleed in anticoagulated atrial fibrillation patients: risk and timing

Cost-effectiveness of population screening for atrial fibrillation: the STROKESTOP study

Bone morphogenetic protein 10: a novel risk marker of ischemic stroke in patients with atrial fibrillation

Ventricular fibrillation in acute myocardial infarction: 20-year trends in the FAST-MI study

Rhythm monitoring, success definition, recurrence, and anticoagulation after atrial fibrillation ablation: results from an EHRA survey

Non-invasive localization of post-infarct ventricular tachycardia exit sites to guide ablation planning: a computational deep learning platform utilizing the 12-lead electrocardiogram and intracardiac electrograms from implanted devices

Upgrading right ventricular pacemakers to biventricular pacing or conduction system pacing: a systematic review and meta-analysis

Disease progression rate is a strong predictor of ventricular arrhythmias in patients with cardiac laminopathies: a primary prevention cohort study

Repeatability of ventricular arrhythmia characteristics on the exercise-stress test in RYR2-mediated catecholaminergic polymorphic ventricular tachycardia

A head-to-head comparison of laser vs. powered mechanical sheaths as first choice and second line extraction tools

Left bundle branch area pacing in congenital heart disease

Cardiology:

Effects of Renal Denervation vs Sham in Resistant Hypertension after Medication Escalation: RADIANCE-HTN TRIO Randomized Clinical Trial.

Coronary microvascular dysfunction is associated with impaired cognitive function: the cerebral-coronary connection study (C3 study)

Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54

Surgical or Percutaneous Coronary Revascularization for Heart Failure: An In Silico Model using Routinely Collected Health Data to Emulate a Clinical Trial.

Single-cell technologies to decipher cardiovascular diseases

An Overview of Telehealth in the Management of Cardiovascular Disease: A Scientific Statement from the American Heart Association

Artificial Intelligence for Contrast-Free MRI: Scar Assessment in Myocardial Infarction Using Deep Learning–Based Virtual Native Enhancement

Coronary Calcium Scoring Improves Risk Prediction in Patients with Suspected Obstructive Coronary Artery Disease

Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies

Outcomes of Pregnancy in Women with Bioprosthetic Heart Valves with or without Valve Dysfunction

Randomized Trials of Percutaneous Microaxial Flow Pump Devices: JACC State-of-the-Art Review

Electrophysiology:

Impact of Low Body Mass Index on Cardiac Tamponade During Catheter Ablation for Atrial Fibrillation

Subcutaneous and Transvenous Defibrillators in Arrhythmogenic Right Ventricular Cardiomyopathy: A Comparison of Clinical and Quality-of-Life Outcomes

Causes of Early Mortality After Ventricular Tachycardia Ablation in Patients with Reduced Ejection Fraction

Direct Oral Anticoagulants vs Vitamin-K Antagonists in Thrombotic Antiphospholipid Syndrome: Meta-analysis of Randomized Controlled Trials

Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation: Histological Evaluation of Left Atrial Appendages

Progression of Atrial Fibrillation after Cryoablation or Drug Therapy

Defibrillation Strategies for Refractory Ventricular Fibrillation

Cardiology:

Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension

Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

Trial of an Intervention to Improve Acute Heart Failure Outcomes: the COACH Trial.

Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial

Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomised trial

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project)

Aspirin vs. Clopidogrel for Chronic Maintenance Monotherapy after Percutaneous Coronary Intervention: the HOST-EXAM Extended Study

Exercise for the Prevention of Anthracycline-induced Functional Disability and Cardiac Dysfunction: The BReast Cancer Randomized EXercise InTervention (BREXIT) Study

Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers

Artificial Intelligence:

Concordance Between Patient-Reported Health Data and Electronic Health Data

Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials

Cardiology:

Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction

Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload

Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomized, open-label, blinded-endpoint clinical trial

Allopurinol versus usual care in UK patients with ischemic heart disease (ALL-HEART): a multicenter, prospective, randomized, open-label, blinded-endpoint trial

Longer-Term All-Cause and Cardiovascular Mortality with Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial

Association between hypotension during 24 h ambulatory blood pressure monitoring and reflex syncope: the SynABPM 1 study

Aldosterone in chronic kidney disease and renal outcomes

Phenotyping the hypertensive heart

Intensive Blood Pressure Lowering in Patients with Malignant Left Ventricular Hypertrophy

Dose-Response to Sacubitril/Valsartan in Patients with Heart Failure and Reduced Ejection Fraction

Acute Myocarditis Associated With Desmosomal Gene Variants

A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes after Acute Myocardial Infarction

Impact of Periprocedural Pulmonary Hypertension on Outcomes after Transcatheter Aortic Valve Replacement

Noninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events

Diaphragmatic Function in Cardiovascular Disease: JACC Review Topic of the Week

Electrophysiology:

Programmed Ventricular Stimulation as an Additional Primary Prevention Risk Stratification Tool in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Study

Highly malignant disease in childhood-onset arrhythmogenic right ventricular cardiomyopathy

Cannabis, cocaine, methamphetamine, and opiates increase the risk of incident atrial fibrillation

Factor XI inhibitors: cardiovascular perspectives

Risk factors for cardiac implantable electronic device infections: a nationwide Danish study

Malignant Purkinje ectopy induced by sodium channel blockers

Characterization of the right ventricular substrate participating in postinfarction ventricular tachycardia

Predicting arrhythmia recurrence following catheter ablation for ventricular tachycardia using late gadolinium enhancement magnetic resonance imaging: Implications of varying scar ranges

Terminal end of retro-aortic root branch: An unrecognized origin for “proximal left anterior fascicle” premature ventricular complexes with narrow QRS duration

Magnetic resonance imaging and histopathology of catheter ablation lesions after ventricular tachycardia ablation in patients with nonischemic cardiomyopathy

Value of genetic testing in the diagnosis and risk stratification of arrhythmogenic right ventricular cardiomyopathy

Electrophysiology:

Association between left atrial epicardial fat, left atrial volume, and the severity of atrial fibrillation

Pulsed Field Ablation of the Porcine Ventricle Using a Focal Lattice-Tip Catheter

Substrate Characterization and Outcomes of Catheter Ablation of Ventricular Arrhythmias in Patients with Mitral Annular Disjunction

Sinus Tachycardia: a Multidisciplinary Expert Focused Review

Composite Index Tagging for PVI in Paroxysmal AF: A Prospective, Multicenter Post-approval Study

Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure

Bipolar Electroporation across the Interventricular Septum: Electrophysiological, Imaging, and Histopathological Characteristics

Cardiac Magnetic Resonance in the Evaluation of Patients with Frequent Premature Ventricular Complexes

Increasing Lesion Dimensions of Bipolar Ablation by Modulating the Surface Area of the Return Electrode

Ablation of Refractory Ventricular Tachycardia Using Intramyocardial Needle Delivered Heated Saline-Enhanced Radiofrequency Energy: A First-in-Man Feasibility Trial

Multielectrode Contact Measurement Can Improve Long-Term Outcome of Pulmonary Vein Isolation Using Circular Single-Pulse Electroporation Ablation

Advanced Techniques for Ethanol Ablation of Left Ventricular Summit Region Arrhythmias

Machine Learning–Enabled Multimodal Fusion of Intra-Atrial and Body Surface Signals in Prediction of Atrial Fibrillation Ablation Outcomes

Electrophsiology:

Aldehyde dehydrogenase 2 and arrhythmogenesis

Near-infrared sensitive nanoparticle-mediated photothermal ablation of ventricular myocardium

Revaluing ablation therapy: History, recent developments, and future Heart Rhythm Society strategy

Impact of atrial fibrillation ablation on activity minutes in patients with cardiac implantable electronic devices

Long-term outcomes of left atrial appendage isolation using cryoballoon in persistent atrial fibrillation

Anatomical considerations and clinical interpretation of the 12-lead ECG in the prone position: a prospective multicenter study

Effect of repeat catheter ablation vs. antiarrhythmic drug therapy among patients with recurrent atrial tachycardia/atrial fibrillation after atrial fibrillation catheter ablation: data from CHINA-AF registry

Same-day discharge for atrial fibrillation ablation: outcomes and impact of ablation modality

Cardiology:

Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials

Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial

Impact on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: a Meta-analysis of Individual Patient Data from Seven Multicenter Randomized Clinical Trials

Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicenter, randomized controlled trial

Association of Thoracic Aortic Aneurysm Size with Long-term Patient Outcomes, The KP-TAA Study

Scleraxis and fibrosis in the pressure-overloaded heart.

Left main coronary disease: evolving management concepts

Immunosuppressive therapy in virus-negative inflammatory cardiomyopathy: 20-year follow-up of the TIMIC trial

Aspirin for Primary Prevention of Cardiovascular Events in Relation to Lipoprotein(a) Genotypes

Early Versus Delayed Non–Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Non-inferiority Study

Cardiac Phenotypes in Secondary Hypertension: JACC State-of-the-Art Review

2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk.

Cardiology:

Aldosterone in chronic kidney disease and renal outcomes

Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: a multinational analysis with external cohort validation

Efficacy of telemedicine for the management of cardiovascular disease: a systematic review and meta-analysis

Empagliflozin in acute Myocardial Infarction: the EMMY trial

Cardiovascular complications of immune checkpoint inhibitors for cancer

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

Management of Infective Endocarditis in People Who Inject Drugs: A Scientific Statement from the American Heart Association

Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment–Elevation Myocardial Infarction: Results of REAL-TIMI 63B

Screening for Cardiac Amyloidosis 5 to 15 Years after Surgery for Bilateral Carpal Tunnel Syndrome

Validated Model for Prediction of Adverse Cardiac Outcome in Patients with Fabry Disease

Ischemic Heart Disease in Young Women: JACC Review Topic of the Week

Electrophysiology:

Rivaroxaban in Rheumatic Heart Disease–Associated Atrial Fibrillation

Attaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST – AFNET 4 trial

Highly malignant disease in childhood-onset arrhythmogenic right ventricular cardiomyopathy

Association of atrial depolarization variability and cardiac autonomic regulation with sudden cardiac death in coronary artery disease

Effectiveness and safety of mexiletine in patients at risk for (recurrent) ventricular arrhythmias: a systematic review

Predictors of recurrence after catheter ablation and electrical cardioversion of atrial fibrillation: an umbrella review of meta-analyse

ESC quality indicators for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed in collaboration with the EHRA

Effect of continuous positive airway pressure therapy on recurrence of atrial fibrillation after pulmonary vein isolation in patients with obstructive sleep apnea: A randomized controlled trial

Impact of atrial fibrillation ablation on activity minutes in patients with cardiac implantable electronic devices

Secretome of atrial epicardial adipose tissue facilitates reentrant arrhythmias by myocardial remodeling

Intramyocardial mapping of ventricular premature depolarizations via septal venous perforators: Differentiating the superior intraseptal region from left ventricular summit origins

Contemporary maternal and fetal outcomes in the treatment of LQTS during pregnancy: Is nadolol bad for the fetus?

Cardiology:

Safety of non-vitamin K antagonist oral anticoagulants: concerns in patients with atrial fibrillation and glomerular hyperfiltration?

Does SGLT1 inhibition add to the benefits of SGLT2 inhibition in the prevention and treatment of heart failure?

Sodium-Glucose Co-Transporter-2 Inhibitors and Cardiac Outcomes among Patients Treated With Anthracyclines

Supernormal Left Ventricular Ejection Fraction, Stroke Volume, and Cardiovascular Risk: Findings from Population-Based Cohort Studies

State of the Science: The Relevance of Symptoms in Cardiovascular Disease and Research: A Scientific Statement From the American Heart Association

Comparative Risks of Initial Aortic Events Associated With Genetic Thoracic Aortic Disease

Polygenic Risk Score Predicts Sudden Death in Patients with Coronary Disease and Preserved Systolic Function

Biomarker Prediction of Complex Coronary Revascularization Procedures in the FOURIER Trial

Severe Mental Illness and Cardiovascular Disease: JACC State-of-the-Art Review

Ancestry, Lipoprotein (a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week

Electrophysiology:

Left bundle branch area pacing outcomes: the multicenter European MELOS study

Premature Ventricular Contractions Are Presaged by a Mechanically Abnormal Sinus Beat

The Association of Clustered Ventricular Arrhythmia and Cycle Length with Scar Burden in Cardiomyopathy

Insights from Simultaneous Left and Right Atrial Septal Mapping in Patients with Persistent Atrial Fibrillation

Use of Wearable Technology and Deep Learning to Improve the Diagnosis of Brugada Syndrome

Guideline-Directed Medical Therapy and the Risk of Death in Primary Prevention Defibrillator Recipients

Atrial Fibrillation and Stress: A 2-Way Street? State-Of-The-Art Review

Electromechanical reciprocity and arrhythmogenesis in long-QT syndrome and beyond

Implantable defibrillators in primary prevention of genetic arrhythmias. A shocking choice?

Arrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator

Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator

Importance of genetic testing in unexplained cardiac arrest

A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Cardiology:

Screening for Atrial Fibrillation in Asymptomatic Older Adults

Critical appraisal of artificial intelligence-based prediction models for cardiovascular disease

Non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease

Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function

Prevalence and Prognostic Implications of Discordant Grading and Flow-Gradient Patterns in Moderate Aortic Stenosis

Management of Patients with Severe Mitral Annular Calcification: JACC State-of-the-Art Review

Mitral Valve Dysfunction in Patients with Annular Calcification: JACC Review Topic of the Week

Routine Pressure Wire Assessment versus Conventional Angiography in the Management of Patients with Coronary Artery Disease: The RIPCORD 2 Trial

Electrophysiology:

Assessment of the Diagnostic Yield of Combined Cardiomyopathy and Arrhythmia Genetic Testing

Post-operative atrial fibrillation and risk of heart failure hospitalization

Short- and Long-Term Risk of Lead Dislodgement Events: Real-World Experience from Product Surveillance Registry

Multielectrode Contact Measurement Can Improve Long-Term Outcome of Pulmonary Vein Isolation Using Circular Single-Pulse Electroporation Ablation

Advanced Techniques for Ethanol Ablation of Left Ventricular Summit Region Arrhythmias

Limitations of Unipolar Signals in Guiding Successful Outflow Tract Premature Ventricular Contraction Ablation

Impact of CPAP on the Atrial Fibrillation Substrate in Obstructive Sleep Apnea: The SLEEP-AF Study

Circumferential Pulmonary Vein Isolation plus Low-Voltage Area Modification in Persistent Atrial Fibrillation: The STABLE-SR-II Trial

Autonomic Changes Are More Durable After Radiofrequency than Pulsed Electric Field Pulmonary Vein Ablation

Safety and Efficacy of a Novel Blunt-Tip Concealed-Needle Epicardial Access Device: First-in-Human Feasibility Study

Short-Coupled Idiopathic Ventricular Fibrillation: A Literature Review with Extended Follow-Up

Cardiology:

Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial

Hypertension in stroke survivors and associations with national premature stroke mortality: data for 2·5 million participants from multinational screening campaigns

Association between Early Left Ventricular Ejection Fraction Improvement after Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes

Which patients with aortic stenosis should be referred to surgery rather than transcatheter aortic valve implantation?

Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry

Timing of cardiac surgery during pregnancy: a patient-level meta-analysis

Sleep-Disordered Breathing and Cardiac Arrhythmias in Adults: Mechanistic Insights and Clinical Implications: A Scientific Statement From the American Heart Association

Donor Macrophages Modulate Rejection after Heart Transplantation

Catastrophic Disruptions in Clinical Trials

Sustained-Release Ivabradine Hemisulfate in Patients with Systolic Heart Failure

Cardiorespiratory Fitness and Mortality Risk across the Spectra of Age, Race, and Sex

Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease

Electrophysiology:

Atrial branch coronary artery stenosis as a mechanism for atrial fibrillation

Ultrasound-guided extracardiac vagal stimulation: new approach for visualization of the vagus nerve during cardioneuroablation

Clinical outcomes of conduction system pacing compared to biventricular pacing in patients requiring cardiac resynchronization therapy

Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing: Results from International LBBAP Collaborative Study Group

Current of injury is an indicator of lead depth and performance during left bundle branch pacing lead implantation

SCN5A overlap syndromes: An open-minded approach

R-on-T and the initiation of reentry revisited: Integrating old and new concepts

Machine-Learning Score Using Stress CMR for Death Prediction in Patients with Suspected or Known CAD

Three-dimensional printing, holograms, computational modelling, and artificial intelligence for adult congenital heart disease care: an exciting future

Hybrid machine learning to localize atrial flutter substrates using the surface 12-lead electrocardiogram

Artificial intelligence in proteomics: new frontiers from risk prediction to treatment?

Cardiology:

Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING).

Association of Left Ventricular Remodeling Assessment by Cardiac Magnetic Resonance with Outcomes in Patients with Chronic Aortic Regurgitation

Atrial septal defect in adulthood: a new paradigm for congenital heart disease

Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

A systematic review and meta-analysis of beta-blockers and renin–angiotensin system inhibitors for preventing left ventricular dysfunction due to anthracyclines or trastuzumab in patients with breast cancer

Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement from the American Heart Association

Effect of Patient-Reported Preprocedural Physical and Mental Health on 10-Year Mortality After Percutaneous or Surgical Coronary Revascularization

Coronary In-Stent Restenosis: JACC State-of-the-Art Review

New Cardiovascular Risk Assessment Techniques for Primary Prevention: JACC Review Topic of the Week

Electrophysiology:

Presenting Pattern of Atrial Fibrillation and Outcomes of Early Rhythm Control Therapy

Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis

Diagnosis and management of arrhythmias in pregnancy

Estimated incidence of previously undetected atrial fibrillation on a 14-day continuous electrocardiographic monitor and associated risk of stroke

Does isolation of the left atrial posterior wall using cryoballoon ablation improve clinical outcomes in patients with persistent atrial fibrillation? A prospective randomized controlled trial

Ventricular tachycardia characteristics and outcomes with catheter ablation vs. antiarrhythmic therapy: insights from the VANISH trial

Long-term clinical impact of permanent pacemaker implantation in patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis

Left ventricular shape predicts arrhythmic risk in fibrotic dilated cardiomyopathy

Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor

A new score for life-threatening ventricular arrhythmias and sudden cardiac death in adults with transposition of the great arteries and a systemic right ventricle

Cardiology:

Machine Learning–Based Models Incorporating Social Determinants of Health vs Traditional Models for Predicting In-Hospital Mortality in Patients With Heart Failure

Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial

Targeting miR-30d reverses pathological cardiac hypertrophy

Deformation of Transcatheter Aortic Valve Prostheses: Implications for Hypoattenuating Leaflet Thickening and Clinical Outcomes

Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function after Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes through Extracellular Vesicles

Prognostic impact of permanent pacemaker implantation after transcatheter aortic valve replacement

Characteristics of Heart Failure with Preserved Ejection Fraction across the Range of Left Ventricular Ejection Fraction

Carotid Artery Stenting: JACC State-of-the-Art Review

Remote and wearable ECG devices with diagnostic abilities in adults: A state-of-the-science scoping review

Electrophysiology:

Evidence to support magnetic resonance conditional labelling of all pacemaker and defibrillator leads in patients with cardiac implantable electronic devices

Exercise training in heart failure with reduced ejection fraction and permanent atrial fibrillation: A randomized clinical trial

How to use bipolar and unipolar electrograms for selecting successful ablation sites of ventricular premature contractions

Successful avoidance of superior vena cava injury during transvenous lead extraction using a tandem femoral-superior approach

Predictors of perforation during lead extraction: Results of the Canadian Lead ExtrAction Risk study

Atrioventricular junction ablation in patients with conduction system pacing leads: A comparison of His-bundle vs left bundle branch area pacing leads

How to perform extrathoracic venous access for cardiac implantable electronic device placement: Detailed description of techniques

Cardiology:

Associations between non-anemic iron deficiency and outcomes following elective cardiac surgery (IDOCS): a prospective cohort study

Biomarker-based risk model to predict cardiovascular events in patients with acute coronary syndromes – Results from BIPass registry

Novel Smooth Muscle Ca2+-Signaling Nanodomains in Blood Pressure Regulation

Cerebral Microbleeds during Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort

Empagliflozin Improves Outcomes in Patients with Heart Failure and Preserved Ejection Fraction Irrespective of Age

Rivaroxaban and aspirin vs. aspirin alone in Asian compared with non-Asian patients with chronic coronary artery disease or peripheral arterial disease: the COMPASS trial

Electrophysiology:

Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy–Associated Putative Pathogenic Gene Variants in UK Biobank Participants

Cost-Effectiveness of Catheter Ablation versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial

Fluoroless versus Conventional Mapping and Ablation of Ventricular Arrhythmias Arising From the Left Ventricular Summit and Interventricular Septum

5S Study: Safe and Simple Single Shot Pulmonary Vein Isolation with Pulsed Field Ablation Using Sedation

Mapping Atrial Fibrillation after Surgical Therapy to Guide Endocardial Ablation

Transesophageal Echocardiography Following Left Atrial Appendage Electrical Isolation: Diagnostic Pitfalls and Clinical Implications

Implantable defibrillators in primary prevention of genetic arrhythmias. A shocking choice?

Cardiology:

Definitions and Standardized Endpoints for Treatment of Coronary Bifurcations

JACC State-Of-The-Art Review

Safety of Provocative Testing With Intracoronary Acetylcholine and Implications for Standard Protocols

False Lumen Flow Assessment by Magnetic Resonance Imaging and Long-Term Outcomes in Uncomplicated Aortic Dissection

Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

Combination Medical Therapy Benefit in Heart Failure with LVEF >45%

Intensive Blood Pressure Lowering in Older People with Hypertension: A Time-to-Benefit Analysis

Finding the “Sweet Spot” for High-Density Lipoprotein

Factors Associated with Physician Tolerance of Uncertainty: an Observational Study

Association of Thromboxane Generation with Survival in Aspirin Users and Nonusers

Electrophysiology:

Inappropriate Sinus Tachycardia: Etiology, Pathophysiology, and Management.

JACC Review Topic of the Week

Association of Neighborhood-Level Material Deprivation with Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study

Temporal Changes in Pulmonary Vein Reconnection during Repeat Catheter Ablation for Early Recurrence of Atrial Fibrillation

Continuous Pericardial Irrigation-Suction Technique to Manage Hemorrhagic Pericardial Effusion Associated With loculated Intrapericardial Thrombus

Simplified Integrated Clinical and Electrocardiographic Algorithm for Differentiation of Wide QRS-Complex Tachycardia: The Basel Algorithm

Short-Coupled Idiopathic Ventricular Fibrillation: A Literature Review with Extended Follow-Up

Pulsed Field Ablation of Left Ventricular Myocardium in a Swine Infarct Model

A new score for life-threatening ventricular arrhythmias and sudden cardiac death in adults with transposition of the great arteries and a systemic right ventricle

Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias

Early and late-onset syncope: insight into mechanisms

Silent brain infarcts impact on cognitive function in atrial fibrillation

Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischemic cardiomyopathy

Influence of Capture Selectivity and Left Intrahisian Block on QRS Characteristics during Left Bundle Branch Pacing

Electrical Posterior Box Isolation in Repeat Ablation for Atrial Fibrillation: A Prospective Randomized Clinical Study

Adjunctive Left Atrial Posterior Wall Isolation in Treating Atrial Fibrillation: Insight from a Large Secondary Analysis

Age and Outcomes of Early Rhythm Control in Patients with Atrial Fibrillation: Nationwide Cohort Study

Spatial Distribution of Idiopathic Ventricular Arrhythmias Originating Around the Pulmonary Root: Lessons from Intracardiac Echocardiography

Critical appraisal of artificial intelligence-based prediction models for cardiovascular disease

Apixaban vs. standard of care after transcatheter aortic valve implantation: the ATLANTIS trial

Coronary Artery and Cardiac Disease in Patients with Type 2 Myocardial Infarction: A Prospective Cohort Study

Endovascular Treatment versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results from the ATTENTION Multicenter Registry

Association of Cardiovascular Health Through Young Adulthood with Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study

Cigarette Smoking, Cessation, and Risk of Heart Failure with Preserved and Reduced Ejection Fraction

Care Models for Acute Chest Pain That Improve Outcomes and Efficiency: JACC State-of-the-Art Review.

Routine Removal of Inferior Vena Cava Filters

Cardiac resynchronization therapy via left bundle branch pacing vs. optimized biventricular pacing with adaptive algorithm in heart failure with left bundle branch block: a prospective, multicenter, observational study

Machine learning–derived major adverse event prediction of patients undergoing transvenous lead extraction: Using the ESC EHRA EORP European lead extraction ConTRolled ELECTRa registry

Microbiological diagnosis in cardiac implantable electronic device infections detected by sonication and next-generation sequencing

Impact of baseline left ventricular volume on left ventricular reverse remodeling after cardiac resynchronization therapy

Electrical Posterior Box Isolation in Repeat Ablation for Atrial Fibrillation: A Prospective Randomized Clinical Study

Statins to prevent pacing-induced cardiomyopathy: Evidence from the bench applied to clinical studies

Dexmedetomidine versus propofol for operator-directed nurse-administered procedural sedation during catheter ablation of atrial fibrillation: A randomized controlled study

Efficacy of catheter ablation from the noncoronary aortic cusp of verapamil-sensitive atrial tachycardia arising near the atrioventricular node

Electrophysiological characteristics of septal perforation during left bundle branch pacing

Importance of newer cardiac magnetic resonance–based risk markers for sudden death prevention in hypertrophic cardiomyopathy: An international multicenter study

The evidence for the implantable loop recorder in patients with inherited arrhythmia syndromes: a review of the literature

Long-term outcomes in a randomized controlled trial of multimodality imaging-guided left ventricular lead placement in cardiac resynchronization therapy

Drug Interactions Affecting Oral Anticoagulant Use

Cardiology:

Quality of Life after Fractional Flow Reserve–Guided PCI Compared With Coronary Bypass Surgery

Gliflozins in the Management of Cardiovascular Disease

Routine Removal of Inferior Vena Cava Filters

Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

Cardiovascular Magnetic Resonance for Rejection Surveillance after Cardiac Transplantation

Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study

Electronic Alerts to Improve Heart Failure Therapy in Outpatient Practice: A Cluster Randomized Trial

Gender Differences in Takotsubo Syndrome

Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction

Prognostic Value of Time in Blood Pressure Target Range among Patients with Heart Failure

Acute Decompensated Heart Failure in the Setting of Acute Coronary Syndrome:

State-Of-The-Art Review

Artificial Intelligence:

Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review

Predicting hospitalisation for heart failure and death in patients with, or at risk of, heart failure before first hospitalisation: a retrospective model development and external validation study

Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: a prespecified exploratory analysis

Cardiology:

Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Treatment for Mild Chronic Hypertension during Pregnancy

Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study

Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial

Prevalence and Prognostic Implications of Left Ventricular Systolic Dysfunction in Adults with Congenital Heart Disease

Expert Consensus Statement on the state of genetic testing for cardiac diseases

Association of Cumulative Blood Pressure with Cognitive Decline, Dementia, and Mortality

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the ACC/AHA Joint Committee on Clinical Practice Guidelines

Electrophysiology:

Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients with an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial

Monogenic and Polygenic Contributions to QTc Prolongation in the Population

Measurement of Midregional Pro-Atrial Natriuretic Peptide to Discover Atrial Fibrillation in Patients with Ischemic Stroke

Management of ventricular tachycardia in patients with ischemic cardiomyopathy: contemporary armamentarium

EHRA consensus on prevention and management of interference due to medical procedures in patients with cardiac implantable electronic devices

How to use digital devices to detect and manage arrhythmias: an EHRA practical guide

Ectopy-triggering ganglionated plexuses ablation to prevent atrial fibrillation: GANGLIA-AF study

Empiric ablation of polymorphic ventricular tachycardia/fibrillation in the absence of a mappable trigger: Prospective feasibility and efficacy of pacemap matching to defibrillator electrograms

Cardiac deceleration capacity as an indicator for cardioneuroablation in patients with refractory vasovagal syncope

Lower body muscle preactivation and tensing mitigate symptoms of initial orthostatic hypotension in young females

Cardiac resynchronization therapy in patients with congenital heart disease and systemic right ventricle

Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort

Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial

Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity

Critical Comparison of Documents from Scientific Societies on Cardiac Amyloidosis: JACC State-of-the-Art Review

Eisenmenger Syndrome: JACC State-of-the-Art Review

Risk of sports-related sudden cardiac death in women

Leadless vs. transvenous single-chamber ventricular pacing in the Micra CED study: 2-year follow-up

Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial

Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation

Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients with Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial

Cardiovascular Complications of Interatrial Conduction Block: JACC Review

Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients with Atrial Fibrillation

Lead-Related Venous Obstruction in Patients with Implanted Cardiac Devices: JACC Review Topic of the Week

Long-term monitoring of arrhythmias with cardiovascular implantable electronic devices in patients with cardiac sarcoidosis

Bradyarrhythmias detected by extended rhythm recording in patients undergoing transcatheter aortic valve replacement (Brady-TAVR Study)

High-density epicardial mapping in Brugada syndrome: Depolarization and repolarization abnormalities

Mechanism of the effects of sodium channel blockade on the arrhythmogenic substrate of Brugada syndrome

Multisite conduction block in the epicardial substrate of Brugada syndrome

Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients with Brugada Syndrome

Rate control drugs differ in the prevention of progression of atrial fibrillation

Antibiotic prophylaxis based on individual infective risk stratification in cardiac implantable electronic device: the PRACTICE study

Rate of device-related infections using an antibacterial envelope in patients undergoing cardiac resynchronization therapy reoperations.

Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract

Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem

Postmortem Interrogation of Cardiac Implantable Electronic Devices: A 15-Year Experience

CT or Invasive Coronary Angiography in Stable Chest Pain

High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality

Towards personalized antithrombotic management with drugs and devices across the cardiovascular spectrum

Heparin use in acute coronary syndromes and cardiovascular interventions: habit or evidence based?

Comprehensive Quality of Life Outcomes with Invasive versus Conservative Management of Chronic Coronary Disease in ISCHEMIA

Beyond Ten-Year Risk: A Cost-Effectiveness Analysis of Statins for the Primary Prevention of Cardiovascular Disease

Trends and Outcomes of Left Ventricular Assist Device Therapy: JACC Focus Seminar: JACC Focus Seminar

Left Ventricular Thrombus Following Acute Myocardial Infarction

24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk

Point-of-care screening for heart failure with reduced ejection fraction using artificial intelligence during ECG-enabled stethoscope examination in London, UK: a prospective, observational, multicenter study

Development and validation of an artificial neural network algorithm to predict mortality and admission to hospital for heart failure after myocardial infarction: a nationwide population-based study

Automated interpretation of systolic and diastolic function on the echocardiogram: a multi-cohort study

Association of N-Terminal Pro–Brain Natriuretic Peptide Concentration in Early Pregnancy with Development of Hypertensive Disorders of Pregnancy and Future Hypertension

Glycosylated apolipoprotein J in cardiac ischemia: molecular processing and circulating levels in patients with acute ischemic events

Comparison of a Pure Plug-Based Versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial

E-Cigarettes and Cardiopulmonary Health: Review for Clinicians

Circulating Metabolome and White Matter Hyperintensities in Females and Males

Association of Lipoprotein (a) With Atherosclerotic Plaque Progression

Evolution of Incidence, Management, and Outcomes over Time in Sports-Related Sudden Cardiac Arrest

Myocardial Fibrosis Predicts Ventricular Arrhythmias and Sudden Death after Cardiac Electronic Device Implantation

Autonomic Neuromodulation for Atrial Fibrillation Following Cardiac Surgery: JACC Review Topic of the Week

Antithrombotic Therapy in Patients with Atrial Fibrillation after Acute Coronary Syndromes or Percutaneous Intervention

Nonsustained Ventricular Tachycardia Is Independently Associated With Sustained Ventricular Arrhythmias in Nonischemic Dilated Cardiomyopathy

Integrating Exercise into Personalized Ventricular Arrhythmia Risk Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy

Predicting Atrial Fibrillation Recurrence by Combining Population Data and Virtual Cohorts of Patient-Specific Left Atrial Models

Arrhythmic Burden and the Risk of Cardiovascular Outcomes in Patients with Paroxysmal Atrial Fibrillation and Cardiac Implanted Electronic Devices

Autonomic Afferent Dysregulation in Atrial Fibrillation

Optimized Computed Tomography Acquisition Protocol for Ethanol Infusion into the Vein of Marshall

Detailed Assessment of Low-Voltage Zones Localization by Cardiac MRI in Patients with Implantable Devices

Randomized Pragmatic Trial of Pacemaker versus Implantable Cardiac Monitor in Syncope and Bifascicular Block

Sinus rhythm QRS amplitude and fractionation in patients with nonischemic cardiomyopathy to identify ventricular tachycardia substrate and location

Five-Year Outcomes of the Partial Oral Treatment of Endocarditis (POET) Trial

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II-Trial.

Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort

Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9) trial.

Generating 3D human cardiac constructs from pluripotent stem cells

Association of Annual N-Terminal Pro-Brain Natriuretic Peptide Measurements with Clinical Events in Patients with Asymptomatic Nonsevere Aortic Stenosis: A Post Hoc Substudy of the SEAS Trial.

Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy

Conservative, surgical, and percutaneous treatment for mitral regurgitation shortly after acute myocardial infarction

Vascular repair and regeneration in cardiometabolic diseases

Secreted Protein Acidic and Rich in Cysteine, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension

Splenic Marginal Zone B Lymphocytes Regulate Cardiac Remodeling After Acute Myocardial Infarction in Mice.

A Score to Assess Mortality after Percutaneous Mitral Valve Repair

Electrophysiology:

Miniseries 1—Part I: the Development of the atrioventricular conduction axis

Miniseries 1—Part II: the comparative anatomy of the atrioventricular conduction axis

Miniseries 1—Part III: ‘Behind the scenes’ in the triangle of Koch

Miniseries 1—Part IV: How frequent are fasciculo-ventricular connections in the normal heart?

Miniseries 2—septal and paraseptal accessory pathways—Part I: The anatomic basis for the understanding of para-Hisian accessory atrioventricular pathways

Miniseries 2—septal and paraseptal accessory pathways—part II: para-Hisian accessory pathways—so-called anteroseptal pathways revisited

Miniseries 2—septal and paraseptal accessory pathways—part III: mid-paraseptal accessory pathways—revisiting bypass tracts crossing the pyramidal space

Miniseries 2—septal and paraseptal accessory pathways—part IV: inferior paraseptal accessory pathways—lessons from surgical and catheter ablation

Leadless left ventricular stimulation with WiSE-CRT System – Initial experience and results from phase I of SOLVE-CRT Study (nonrandomized, roll-in phase)

European Society of Cardiology Quality Indicators for the care and outcomes of cardiac pacing: developed by the Working Group for Cardiac Pacing Quality Indicators in collaboration with the European Heart Rhythm Association of the European Society of Cardiology

2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) with the special contribution of the European Heart Rhythm Association (EHRA)

Cardiology:

Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings from the EXTEND-DAPT Study

Magnetically Controlled Capsule Endoscopy for Assessment of Antiplatelet Therapy–Induced Gastrointestinal Injury

Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough

Management of Atrial Fibrillation in Patients 75 Years and Older: JACC Review

Risk of Heart Failure in Patients with Nonalcoholic Fatty Liver Disease: JACC Review 

Electrophysiology:

Left bundle branch–optimized cardiac resynchronization therapy (LOT-CRT): Results from an international LBBAP collaborative study group

Sinus Node Sparing Hybrid Thoracoscopic Ablation Outcomes in Patients with Inappropriate Sinus Tachycardia (SUSRUTA-IST) Registry

Role of subcutaneous implantable loop recorder for the diagnosis of arrhythmias in Brugada syndrome: A United Kingdom single-center experience

Ventricular arrhythmias in athletes: Role of a comprehensive diagnostic workup

Structure and function of the ventricular tachycardia isthmus

Interpreting device diagnostics for lead failure

The V6-V1 inter-peak interval: a novel criterion for the diagnosis of left bundle branch capture

Cardiovascular magnetic resonance-based predictors of complete left ventricular systolic functional recovery after rhythm restoration in patients with atrial tachyarrhythmia

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection

Colchicine in Cardiovascular Disease: In-Depth Review

Coronary Atherosclerotic Plaque Regression: JACC State-of-the-Art Review

Direct Oral Anticoagulants versus Warfarin in Patients with Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials with Interaction Testing by Age and Sex

4-Year Outcomes After Left Atrial Appendage Closure Versus Non-warfarin Oral Anticoagulation for Atrial Fibrillation

Risk of Subsequent Stroke Among Patients Receiving Outpatient vs Inpatient Care for Transient Ischemic Attack

Cardiovascular magnetic resonance imaging in suspected cardiac tumor: a multicenter outcomes study

Intramyocardial Hemorrhage and the “Wave Front” of Reperfusion Injury Compromising Myocardial Salvage

Evaluation of Factors Underlying Sex-Based Disparities in Cardiovascular Care in Adults with Self-reported Premature Atherosclerotic Cardiovascular Disease

The year in cardiovascular medicine 2021: diabetes and metabolic disorders

The year in cardiovascular medicine 2021: interventional cardiology

The year in cardiovascular medicine 2021: cardio-oncology

The year in cardiovascular medicine 2021: heart failure and cardiomyopathies

The year in cardiovascular medicine 2021: dyslipidemia

The year in cardiovascular medicine 2021: valvular heart disease

The year in cardiovascular medicine 2021: acute cardiovascular care and IHD

The year in cardiovascular medicine 2021: digital health and innovation

Infectious consequences of hematoma from cardiac implantable electronic device procedures and the role of the antibiotic envelope: A WRAP-IT trial analysis

Lower rate limit for pacing by cardiac resynchronization defibrillators: Should lower rate programming be reconsidered?

Clinician needs and perceptions about cardioneuroablation for recurrent vasovagal syncope: An international clinician survey

Skin sympathetic nerve activity as a biomarker of fitness

Impact of High-Power Short-Duration Radiofrequency Ablation on Esophageal Temperature Dynamic

Brugada Syndrome: New Insights from Cardiac Magnetic Resonance and Electroanatomical Imaging

Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report from the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects

Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report from the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

Safety/Efficacy of DOAC versus Aspirin for Reduction of Risk of Cerebrovascular Events Following VT Ablation

Using Machine-Learning for Prediction of the Response to Cardiac Resynchronization Therapy: The SMART-AV Study

Arrhythmias Utilizing Concealed Nodoventricular or His-Ventricular Pathways: A Structured Approach to Diagnosis and Management

P-Wave Morphology in Focal Atrial Tachycardia: An Updated Algorithm to Predict Site of Origin

Radiofrequency Energy Applications Targeting Significant Residual Leaks after Watchman Implantation: A Prospective, Multicenter Experience

Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy

Temporal Association of Atrial Fibrillation with Cardiac Implanted Electronic Device Detected Heart Failure Status

Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results from the CABANA Trial

Postimplant PDE-5i use was associated with lower mortality and ischemic strokes in patients with centrifugal flow LVADs.

Remote Speech Analysis in the Evaluation of Hospitalized Patients with Acute Decompensated Heart Failure

Prognostic value of comprehensive intracoronary physiology assessment early after heart transplantation

Feasibility and Potential Impact of HTX from Adult Donors After Circulatory Death

Effects of canagliflozin on human myocardial redox signaling.

Sodium glucose co-transporter inhibitors and heart failure outcomes across different patient populations

The effect of intravenous ferric carboxymaltose on cardiac reverse remodelling following cardiac resynchronization therapy—the IRON-CRT trial

Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study

Long-term safety and efficacy of anacetrapib in patients with atherosclerotic vascular disease.

Alirocumab does not reduced MACE among ACS patients with a history of Heart Failure.

Dual antithrombotic treatment in chronic coronary syndrome: European Society of Cardiology criteria vs. CHADS-P₂A₂RC score

Comparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials

Cardiology:

Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial Inflammation

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy

Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy

Early Hospital Discharge Following PCI for Patients With STEMI

Electrophysiology:

Temporal Association Between Episodes of Atrial Fibrillation and Risk of Ischemic Stroke

Medical therapies for prevention of cardiovascular and renal events in patients with atrial fibrillation and diabetes mellitus

Reconstituting electrical conduction in soft tissue: the path to replace the ablationist

Targeting non-pulmonary vein triggers in persistent atrial fibrillation: results from a prospective, multicentre, observational registry

Electrocardiographic characteristics and ablation of ventricular arrhythmias originating from the basal inferoseptal area

Epicardial ablation of ventricular tachycardia in patients with structural heart disease: a single-centre experience over 12 years

Driving Restrictions and Early Arrhythmias in Patients Receiving a Secondary Prevention Implantable Cardioverter-Defibrillator (DREAM-ICD-II study)

Mechanisms of Sinoatrial Node Dysfunction in Heart Failure with Preserved Ejection Fraction

Periodic Repolarization Dynamics Identifies ICD-responders in Non-ischemic Cardiomyopathy: A DANISH Substudy

Cardiology:

Myocarditis after Covid-19 Vaccination in a Large Health Care Organization

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes

Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR

Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

Ticagrelor monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention: TWILIGHT-HBR

Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis

Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance

Reduction in Acute Limb Ischemia With Rivaroxaban Versus Placebo in Peripheral Artery Disease After Lower Extremity Revascularization: Insights From VOYAGER PAD

Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG

Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review

JACC State-Of-The-Art Review

Electrophysiology:

AV junction ablation and cardiac resynchronization for patients with permanent atrial fibrillation and narrow QRS: the APAF-CRT mortality trial

Application of artificial intelligence to the electrocardiogram

Lower risk of stroke after alcohol abstinence in patients with incident atrial fibrillation: a nationwide population-based cohort study

Epigenetic Age and the Risk of Incident Atrial Fibrillation

Exercise-Induced Ventricular Ectopy and Cardiovascular Mortality in Asymptomatic Individuals

Longitudinal Oral Anticoagulant Adherence Trajectories in Patients With Atrial Fibrillation

Microcirculatory Resistance Predicts Allograft Rejection and Cardiac Events After Heart Transplantation

Substrate Characterization and Outcome of Catheter Ablation of Ventricular Tachycardia in Patients With Nonischemic Cardiomyopathy and Isolated Epicardial Scar

Shared Decision-Making in Cardiac Electrophysiology Procedures and Arrhythmia Management

Cardiac Resynchronization Therapy Response Is Equalized in Men and Women by Electrical Optimization: PR Matters

A Randomized Trial of His Pacing Versus Biventricular Pacing in Symptomatic HF Patients With Left Bundle Branch Block (His-Alternative)

Outcomes associated with pacemaker implantation following transcatheter aortic valve replacement: A nationwide cohort study

Permanent pacemaker implantation late after transcatheter aortic valve implantation

Three-year outcome after transcatheter aortic valve implantation: Comparison of a restrictive versus a liberal strategy for pacemaker implantation

Extracellular matrix remodeling precedes atrial fibrillation: Results of the PREDICT-AF trial

Recommendations regarding cardiac stereotactic body radiotherapy for treatment refractory ventricular tachycardia

Cardiology:

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality

Empagliflozin Effects on Pulmonary Artery Pressure in Patients with Heart Failure

Results From the EMBRACE-HF Trial

Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure with Preserved Ejection Fraction: The HFpEF-Stress Trial

Therapeutic Manipulation of Myocardial Metabolism: JACC State-of-the-Art Review

Patient Selection for Intensive Blood Pressure Management Based on Benefit and Adverse Events

Randomized Trial of Interleukin-6 Receptor Inhibition in Patients with Acute ST-Segment Elevation Myocardial Infarction

Effects of Fluoroquinolones on Outcomes of Patients with Aortic Dissection or Aneurysm

Thromboembolism in Heart Failure Patients in Sinus Rhythm: Epidemiology, Pathophysiology, Clinical Trials, and Future Direction

Electrophysiology:

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

Relationship of LVEF and Myocardial Scar to Long-Term Mortality Risk and Mode of Death in Patients with Nonischemic Cardiomyopathy

Prognostic Value of Nonischemic Ringlike Left Ventricular Scar in Patients With Apparently Idiopathic Nonsustained Ventricular Arrhythmias

Marshall bundle elimination, Pulmonary vein isolation, and Line completion for ANatomical ablation of persistent atrial fibrillation (Marshall-PLAN): Prospective, single-center study

Temperature- and flow-controlled ablation/very-high-power short-duration ablation vs conventional power-controlled ablation: Comparison of focal and linear lesion characteristics

Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death

Burst Exercise Testing Can Unmask Arrhythmias in Patients with Incompletely Penetrant Catecholaminergic Polymorphic Ventricular Tachycardia

Outcome of a Modified Sympathecotomy for Cardiac Neuromodulation of Untreatable Ventricular Tachycardia

Optimizing Impedance Change Measurement During Radiofrequency Ablation Enables More Accurate Characterization of Lesion Formation

Evolving Cardiac Electrical Therapies for Advanced Heart Failure Patients

Cardiology:

Management of Antithrombotic Therapy after Acute Coronary Syndromes

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality

Finding new drugs for heart-valve disease: An artificial intelligence-enabled drug screen finds small molecules that can correct dysfunctional gene networks in aortic valve disease.

Utility of a Deep-Learning Algorithm to Guide Novices to Acquire Echocardiograms for Limited Diagnostic Use

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner

How Should We Sequence the Treatments for Heart Failure and a Reduced Ejection Fraction? A Redefinition of Evidence-Based Medicine

Prognostic Value of Coronary CT Angiography in Patients with Non–ST-Segment Elevation Acute Coronary Syndromes

Mitochondria-Rich Extracellular Vesicles from Autologous Stem Cell–Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium

Does Patient-Physician Gender Concordance Influence Patient Perceptions or Outcomes? Cardiovascular Medicine and Society

Spironolactone in Patients with Heart Failure, Preserved Ejection Fraction, and Worsening Renal Function

Managing Patients with Short-Term Mechanical Circulatory Support: JACC Review Topic of the Week

How to Build an Antiracist Cardiovascular Culture, Community, and Profession: Cardiovascular Medicine and Society

Electrophysiology:

Screening for Atrial Fibrillation in the Older Population: A Randomized Clinical Trial

Discovering and Visualizing Disease-Specific Electrocardiogram Features Using Deep Learning Proof-of-Concept in Phospholamban Gene Mutation Carriers

Circular Multielectrode Pulsed Field Ablation Catheter Lasso Pulsed Field Ablation

Lesion Characteristics, Durability, and Effect on Neighboring Structures

Does Pulsed Field Ablation Regress Over Time? A Quantitative Temporal Analysis of Pulmonary Vein Isolation

Oral Anticoagulants in Extremely High Risk Very Elderly (>90 years) Patients with Atrial Fibrillation

Arrhythmias and Device Therapies in Patients with Cancer Therapy-Induced Cardiomyopathy

Ventricular tachycardia burden reduction after substrate ablation: predictors of recurrence

Relationship between device-detected burden and duration of atrial fibrillation and risk of ischemic stroke

Reassessing the role of antitachycardia pacing in fast ventricular arrhythmias in primary prevention implantable cardioverter-defibrillator recipients: Results from MADIT-RIT

Active compression versus standard anterior-posterior defibrillation for external cardioversion of atrial fibrillation: A prospective randomized study

Epicardial course of the septopulmonary bundle: Anatomical considerations and clinical implications for roof line completion

Cardiology:

Time to Clinical Benefit of Dapagliflozin and Significance of Prior Heart Failure Hospitalization in Patients with Heart Failure with Reduced Ejection Fraction

Sex-Related Differences in Cardiac Channelopathies: Implications for Clinical Practice

Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction with Nonobstructive Coronary Arteries in Women

Pathophysiology of Takotsubo Syndrome: JACC State-of-the-Art Review

Cardiac Involvement in Fabry Disease: JACC Review Topic of the Week

Pooled Analysis of PFO Occluder Device Trials in Patients with PFO and Migraine

Natriuretic Equation to Predict Loop Diuretic Response in Patients with Heart Failure

2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure with Reduced Ejection Fraction

Electrophysiology and Artificial Intelligence:

Magnetic Resonance Imaging in Patients with Cardiac Implantable Electronic Devices with Abandoned Lead

Use of Artificial Intelligence and Deep Neural Networks in Evaluation of Patients with Electrocardiographically Concealed Long QT Syndrome from the Surface 12-Lead Electrocardiogram

Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead Electrocardiogram and Help Identify Those at Risk of AF-Related Stroke

MicroRNA Biophysically Modulates Cardiac Action Potential via Directly Binding to Ion Channel

Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results from the CABANA Trial

Randomized Trial of Ivabradine in Patients with Hyperadrenergic Postural Orthostatic Tachycardia Syndrome

RBBB ventricular tachycardia in ARVC more commonly originates from the right ventricle: Criteria for identifying chamber of origin

Effect of pacemaker implantation after transcatheter aortic valve replacement on long- and mid-term mortality

Anticoagulation for stroke prevention in patients with hypertrophic cardiomyopathy and atrial fibrillation: A review

Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: Results from the International LBBAP Collaborative Study Group

Efficiency of the RADPAD Surgical Cap in Reducing Brain Exposure During Pacemaker and Defibrillator Implantation

Concomitant Pulmonary Vein and Posterior Wall Isolation Using Cryoballoon With Adjunct Radiofrequency in Persistent Atrial Fibrillation

A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK)

Fractionated Epicardial Electrograms: Implication for Mechanism of the Brugada Pattern: Global EP Rounds

Cardiology:

An Electronically Delivered Patient-Activation Tool for Intensification of Medications for Chronic Heart Failure with Reduced Ejection Fraction

Research Priorities in Atrial Fibrillation Screening: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop

Rivaroxaban Plus Aspirin in Obese and Overweight Patients with Vascular Disease in the COMPASS Trial

Mortality 10 Years After Percutaneous or Surgical Revascularization in Patients with Total Coronary Artery Occlusions

2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease.

Electrophysiology:

Periaortic Ventricular Tachycardias in Nonischemic Cardiomyopathy: Substrate and Electrocardiographic Correlations

High-Intensity Ultrasound Catheter Ablation Achieves Deep, Mid-Myocardial Lesions In-Vivo

Close-coupled Pacing to Identify the 'Functional' Substrate of Ventricular Tachycardia: Long-term Outcomes of the Paced Electrogram Feature Analysis (PEFA) Technique

Specific Electrogram Characteristics Impact Substrate Ablation Target Area in Patients with Scar-Related Ventricular Tachycardia - Insights from Automated Ultra-High-Density Mapping

Diagnosis, family screening, and treatment of inherited arrhythmogenic diseases in Europe: results of the European Heart Rhythm Association Survey

Imaging and Pathological Evaluation of Deep Intramural Ventricular Tachycardia After Combined Bipolar and Ethanol Ablation

Multicenter Study of Dynamic High-Density Functional Substrate Mapping Improves Identification of Substrate Targets for Ischemic Ventricular Tachycardia Ablation

Cardiology:

Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease

Striking Similarities of Multisystem Inflammatory Syndrome in Children and a Myocarditis-Like Syndrome in Adults: Overlapping Manifestations of COVID-19

Icosapent-ethyl is the first non–low-density lipoprotein–lowering treatment that has been shown to reduce coronary artery bypass grafting in a blinded, randomized trial.

Electrophysiology:

Primary Results From the Understanding Outcomes With the S-ICD in Primary Prevention Patients With Low Ejection Fraction (UNTOUCHED) Trial

Myocardial Fibrosis as a Predictor of Sudden Death in Patients With Coronary Artery Disease

Calcium-Induced Autonomic Denervation in Patients With Post-Operative Atrial Fibrillation

Left ventricular summit arrhythmias with an abrupt V3 transition: Anatomy of the aortic interleaflet triangle vantage point

Premature ventricular complex site of origin and ablation outcomes in patients with prior myocardial infarction

Risk of arrhythmic events after alcohol septal ablation for hypertrophic cardiomyopathy using continuous implantable cardiac monitoring

The rationale for repurposing funny current inhibition for management of ventricular arrhythmia

Artificial Intelligence:

Artificial intelligence for COVID-19: saviour or saboteur?

Predicting the risk of developing diabetic retinopathy using deep learning

Development and dissemination of infectious disease dynamic transmission models during the COVID-19 pandemic: what can we learn from other pathogens and how can we move forward?

Electrophysiology:

Cardiac Pressure Overload Decreases ETV1 Expression in the Left Atrium, Contributing to Atrial Electrical and Structural Remodeling

The Diagnostic Value of Cardiac Deceleration Capacity in Vasovagal Syncope

Long-Term Evaluation of the Vagal Denervation by Cardioneuroablation using Holter and Heart Rate Variability

A pragmatic ablation approach targeting CMR-detected atrial fibrosis plus PVI was not more effective than PVI alone in an unselected population undergoing atrial fibrillation ablation with low fibrosis burden.

Novel Neuromodulation Approach to Improve Left Ventricular Contractility in Heart Failure

The Clinical Application of the Deep Learning Technique for Predicting Trigger Origins in Patients with Paroxysmal Atrial Fibrillation with Catheter Ablation

Cardiac Inflammation Impedes Response to Cardiac Resynchronization Therapy in Patients with Idiopathic Dilated Cardiomyopathy

Superior-Type Fast-Slow Atrioventricular Nodal Reentrant Tachycardia Phenotype Mimicking the Slow-Fast Type

Complex Re-Entrant Arrhythmias Involving the His-Purkinje System: A Structured Approach to Diagnosis and Management

Prevalence of Undiagnosed Sleep Apnea in Patients with Atrial Fibrillation and its Impact on Therapy

A Standardized and Comprehensive Approach to the Management of Cardiogenic Shock

Cardiology:

Complete Hemodynamic Profiling with Pulmonary Artery Catheters in Cardiogenic Shock Is Associated with Lower In-Hospital Mortality

Polypill with or without Aspirin in Persons without Cardiovascular Disease

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

Randomized Pilot Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography After Cardiac Arrest Without ST-Segment Elevation: The PEARL Study

Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure])

Brain Injury After Transcatheter Replacement of Bicuspid Versus Tricuspid Aortic Valves

Gerotechnology for Older Adults with Cardiovascular Diseases: JACC State-of-the-Art Review

Cardiopulmonary Hemodynamics in Pulmonary Hypertension and Heart Failure: JACC Review Topic of the Week

Thrombosis:

Advanced Management of Intermediate- and High-Risk Pulmonary Embolism:

JACC Focus Seminar

Venous Thromboembolism Associated with Pregnancy: JACC Focus Seminar

Antithrombotic Management of Venous Thromboembolism: JACC Focus Seminar

Chronic Thromboembolic Pulmonary Hypertension: JACC Focus Seminar

Ventricular Tachycardia:

Intracardiac Impedance: A Novel Marker for Computed Tomography-Derived Wall Thinning in Ventricular Tachycardia Ablation

Safety and Outcomes of Ventricular Tachycardia Substrate Ablation During Sinus Rhythm: A Prospective Multicenter Registry

Intramural Venous Ethanol Infusion for Refractory Ventricular Arrhythmias: Outcomes of a Multicenter Experience

Modified Precordial Lead R-Wave Deflection Interval Predicts Left- and Right-Sided Idiopathic Outflow Tract Ventricular Arrhythmias

Increased Rate of Pump Thrombosis and Cardioembolic Events Following Ventricular Tachycardia Ablation in Patients Supported With Left Ventricular Assist Devices

Man vs machine: Performance of manual vs automated electrocardiogram analysis for predicting the chamber of origin of idiopathic ventricular arrhythmia

Signature signal strategy: Electrogram-based ventricular tachycardia mapping

Digital Health:

Digital health for primary prevention of cardiovascular disease: Promise to practice

A comprehensive artificial intelligence–enabled electrocardiogram interpretation program

Utilizing electronic health data and machine learning for the prediction of 30-day unplanned readmission or all-cause mortality in heart failure

Digital health innovation in cardiology

Electrophysiology:

Drug-Induced Arrhythmias: A Scientific Statement from the American Heart Association

Arrhythmogenic Cardiomyopathy: A contemporary review of the history of arrhythmogenic cardiomyopathy highlighting the early discoverers and recent genetic work

Long-Term Follow-Up of Patients with Tetralogy of Fallot and Implantable Cardioverter Defibrillator: The DAI-T4F Nationwide Registry

In-hospital and long-term outcomes among patients with spontaneous coronary artery dissection presenting with ventricular tachycardia/fibrillation

Preimplantation inter-lead ECG heterogeneity is superior to QRS complex duration in predicting mechanical super-response in patients with non–left bundle branch block receiving cardiac resynchronization therapy

His-bundle and left bundle pacing with optimized atrioventricular delay achieve superior electrical synchrony over endocardial and epicardial pacing in left bundle branch block patients

Drivers of hospitalization in atrial fibrillation: A contemporary review

Percutaneous recanalization of superior vena cava occlusions for cardiac implantable electronic device implantation: Tools and techniques

Discriminating electrocardiographic responses to His-bundle pacing using machine learning

Cardiology:

Colchicine in Patients with Chronic Coronary Disease

Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Comparison Between Ticagrelor and Clopidogrel in Elderly Patients with an Acute Coronary Syndrome: Insights from the SWEDEHEART Registry

Deliberating the Diagnostic Dilemma of Heart Failure with Preserved Ejection Fraction

Evaluation and Management of Patients with Stable Angina: Beyond the Ischemia Paradigm: JACC State-of-the-Art Review

Electrophysiology:

Effectiveness of Deep Sedation for Patients with Intractable Electrical Storm Refractory to Antiarrhythmic Drugs

Primary Results from the Understanding Outcomes with the S-ICD in Primary Prevention Patients with Low Ejection Fraction (UNTOUCHED) Trial

Exercise Training-Induced Repolarization Abnormalities Masquerading as Congenital Long QT Syndrome

Ablation of Atrial Fibrillation Without Left Atrial Appendage Imaging in Patients Treated with Direct Oral Anticoagulants

Complete Electroanatomic Imaging of the Diastolic Pathway Is Associated with Improved Freedom from Ventricular Tachycardia Recurrence

Flutter Wave Morphology of Peri-Mitral Atrial Flutters Is Mainly Determined by Right Atrial Activation: Insights from High-Resolution Mapping

Novel Cine-ECG Derived from Standard 12-Lead ECG Enables Right Ventricle Outflow Tract Localization of Electrical Substrate in Patients with Brugada Syndrome

Immunosuppressive Therapy and Risk Stratification of Patients With Myocarditis Presenting With Ventricular Arrhythmias

Para-Hisian Pacing During Sinus Rhythm: Establishing Threshold Values to Distinguish Nodal from Septal Pathway Conduction

Impact of Nonalcoholic Fatty Liver Disease on Arrhythmia Recurrence Following Atrial Fibrillation Ablation

Sudden cardiac arrest with shockable rhythm in patients with heart failure

Cardiology:

NEJM, Clinical Practice: Secondary Mitral Regurgitation

Clinical Features and Outcomes of Pregnancy-Related Acute Aortic Dissection

Misclassification of Hospital Performance Under the Hospital Readmissions Reduction Program: Implications for Value-Based Programs

A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial

Contemporary Diagnosis and Management of Rheumatic Heart Disease: Implications for Closing the Gap: A Scientific Statement From the American Heart Association

Effect of Pre-Hospital Crushed Prasugrel Tablets in Patients with STEMI Planned for Primary Percutaneous Coronary Intervention: The Randomized COMPARE CRUSH Trial

Left Ventricular Unloading is Associated with Lower Mortality in Cardiogenic Shock Patients Treated with Veno-Arterial Extracorporeal Membrane Oxygenation: Results from An International, Multicenter Cohort Study

Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction

Structural Deterioration of Transcatheter Versus Surgical Aortic Valve Bioprostheses in the PARTNER-2 Trial

Molecular Imaging of Apoptosis in Atherosclerosis by Targeting Cell Membrane Phospholipid Asymmetry

Artificial Intelligence: 

Automated and partly automated contact tracing: a systematic review to inform the control of COVID-19

Chest x-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: a prospective study of diagnostic accuracy for culture-confirmed disease

Electrophysiology:

NEJM: Early Rhythm-Control Therapy in Patients with Atrial Fibrillation

Computerized Analysis of the Ventricular Fibrillation Waveform Allows Identification of Myocardial Infarction: A Proof‐of‐Concept Study for Smart Defibrillator Applications in Cardiac Arrest

Inflammation as a Predictor of Recurrent Ventricular Tachycardia After Ablation in Patients with Myocarditis

Automated electrocardiographic quantification of myocardial scar in patients undergoing primary prevention implantable cardioverter-defibrillator implantation: Association with mortality and subsequent appropriate and inappropriate therapies

Diagnostic yield and long-term outcome of nonischemic sudden cardiac arrest survivors and their relatives: Results from a tertiary referral center

Higher baseline cardiorespiratory fitness is associated with lower arrhythmia recurrence and death after atrial fibrillation ablation

Long-term outcomes of ventricular tachycardia substrate ablation incorporating hidden slow conduction analysis

Purkinje system hyperexcitability and ventricular arrhythmia risk in type 3 long QT syndrome

Electrocardiographic interpretation of pacemaker algorithms enabling minimal ventricular pacing

Use of virtual visits for the care of the arrhythmia patient

Cardiology:

Five-Year Health Status After Self-expanding Transcatheter or Surgical Aortic Valve Replacement in High-risk Patients With Severe Aortic Stenosis

Rivaroxaban and Aspirin in Patients with Symptomatic Lower Extremity Peripheral Artery Disease

Angiotensin-Neprilysin Inhibition and Renal Outcomes in Heart Failure With Preserved Ejection Fraction

Diagnostic Yield of Electroanatomic Voltage Mapping in Guiding Endomyocardial Biopsies

Machine Learning Improves Cardiovascular Risk Definition for Young, Asymptomatic Individuals

Artificial Intelligence:

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

Electrophysiology:

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation

Mortality in Patients with Atrial Fibrillation Receiving Nonrecommended Doses of Direct Oral Anticoagulants

Targeted Left Ventricular Lead Implantation Strategy for Non-Left Bundle Branch Block Patients: The ENHANCE CRT Study

RV Tissue Heterogeneity on CT: A Novel Tool to Identify the VT Substrate in ARVC

Prevalence and Prognostic Impact of Pathogenic Variants in Patients with Dilated Cardiomyopathy Referred for Ventricular Tachycardia Ablation

Are Contemporary Smartwatches and Mobile Phones Safe for Patients with Cardiovascular Implantable Electronic Devices?

Multicenter Study of Dynamic High-Density Functional Substrate Mapping Improves Identification of Substrate Targets for Ischemic Ventricular Tachycardia Ablation

Strategies for Catheter Ablation of Left Ventricular Papillary Muscle Arrhythmias

An Institutional Experience

Initial Experience, Safety, and Feasibility of Left Bundle Branch Area Pacing

A Multicenter Prospective Study

Cardiology:

Association between high blood pressure and long-term cardiovascular events in young adults: systematic review and meta-analysis

Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: One-Year Results of the CANOA Randomized Clinical Trial

Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation

Artificial Intelligence to measure coronary artery flow

Automated Recognition of Regional Wall Motion Abnormalities Through Deep Neural Network Interpretation of Transthoracic Echocardiography

Intracranial Arterial Calcification: Prevalence, Risk Factors, and Consequences

Electgrophysiology:

Impact of Left Ventricular Function and Heart Failure Symptoms on Outcomes Post Ablation of Atrial Fibrillation in Heart Failure: CASTLE-AF Trial

Long-Term Outcome in High-Risk Patients with Hypertrophic Cardiomyopathy after Primary Prevention Defibrillator Implants

Pulmonary Vein Isolation with Single Pulse Irreversible Electroporation: A First in Human Study in 10 Patients with Atrial Fibrillation

Power, Lesion Size Index and Oesophageal Temperature Alerts during Atrial Fibrillation Ablation: A Randomized Study

An International Multicenter Evaluation of Inheritance Patterns, Arrhythmic Risks, and Underlying Mechanisms of CASQ2-Catecholaminergic Polymorphic Ventricular Tachycardia

Association of Autoimmune Vasculitis and Incident Atrial Fibrillation: A Population‐Based Case‐Control Study

High-resolution, live, directional mapping

Cardiology:

Multimodality Imaging in Evaluation of Cardiovascular Complications in Patients With COVID-19: JACC Scientific Expert Panel

Altered Hemodynamics and End-Organ Damage in Heart Failure

Impact on the Lung and Kidney

Current Evidence and Recommendations for Coronary CTA First in Evaluation of Stable Coronary Artery Disease

Nonculprit Lesion Severity and Outcome of Revascularization in Patients with STEMI and Multivessel Coronary Disease

Short-term and Long-term Feasibility, Safety, and Efficacy of High-Intensity Interval Training in Cardiac Rehabilitation

Artificial Intelligence:

Effect of artificial intelligence-based triaging of breast cancer screening mammograms on cancer detection and radiologist workload: a retrospective simulation study

Artificial intelligence in medical imaging: switching from radiographic pathological data to clinically meaningful endpoints

The myth of generalisability in clinical research and machine learning in health care

Electrophysiology:

Risk of Arrhythmic Events Following Alcohol Septal Ablation for Hypertrophic Cardiomyopathy Using Continuous Implantable Cardiac Monitoring

Predictors of long-term mortality after catheter ablation of ventricular tachycardia in a contemporary cohort of patients with structural heart disease

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality

Significance of fragmented QRS complexes for predicting new-onset atrial fibrillation after cavotricuspid isthmus–dependent atrial flutter ablation

Acute and long-term results of bipolar radiofrequency catheter ablation of refractory ventricular arrhythmias of deep intramural origin

Anatomic approach with bipolar ablation between the left pulmonic cusp and left ventricular outflow tract for left ventricular summit arrhythmias

Percutaneous approaches for retrieval of an embolized or malpositioned left atrial appendage closure device: A multicenter experience

Axillary vein puncture guided by ultrasound vs cephalic vein dissection in pacemaker and defibrillator implant: A multicenter randomized clinical trial

Modern mapping and ablation techniques to treat ventricular arrhythmias from the left ventricular summit and interventricular septum

Cardiology:

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

Atherosclerotic Plaque Healing

The Effect of Adding Ticagrelor to Standard Aspirin on Saphenous Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting (POPular CABG): A Randomized, Double-Blind, Placebo-Controlled Trial

Renal and Cardiovascular Effects of SGLT2 Inhibition in Combination with Loop Diuretics in Patients with Type 2 Diabetes and Chronic Heart Failure: The RECEDE-CHF Trial

Coronary Computed Tomography Angiography from Clinical Uses to Emerging Technologies

In patients with multivessel CAD and diabetes, CABG was associated with improved long-term mortality and freedom from MACCEs compared with PCI.

Weekly Best Selection:

Electrophysiology:

Atrial Arrhythmias in Clinically Manifest Cardiac Sarcoidosis: Incidence, Burden, Predictors, and Outcomes

Machine Learning to Classify Intracardiac Electrical Patterns During Atrial Fibrillation

Long-Term Outcome After Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy

Efficacy of an Adjunctive Electrophysiological Test–Guided Left Atrial Posterior Wall Isolation in Persistent Atrial Fibrillation Without a Left Atrial Low-Voltage Area

Bilateral Bundle Branch Area Pacing to Achieve Physiological Conduction System Activation

Impact of High-Power Short-Duration Radiofrequency Ablation on Long-Term Lesion Durability for Atrial Fibrillation Ablation

Cardiology:

General versus Local Anesthesia with Conscious Sedation in Transcatheter Aortic Valve Implantation: The Randomized SOLVE-TAVI Trial

Stress Myocardial Perfusion Imaging vs Coronary Computed Tomographic Angiography for Diagnosis of Invasive Vessel-Specific Coronary Physiology

Feasibility of using deep learning to detect coronary artery disease based on facial photo

Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention

Pulmonary Artery Denervation for Patients with Residual Pulmonary Hypertension After Pulmonary Endarterectomy

Imaging of Clinically Unrecognized Myocardial Fibrosis in Patients with Suspected Coronary Artery Disease

Machine Learning Assessment of Left Ventricular Diastolic Function Based on Electrocardiographic Features

Electrophysiolohy:

Integrated management of atrial fibrillation in primary care: results of the ALL-IN cluster randomized trial

An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins

Impact of interruptions in radiofrequency energy delivery on lesion characteristics: These data suggest that if disruption in energy delivery occurs, lesions may need closer spacing to avoid gaps.

An Artificial Intelligence-Enabled ECG Algorithm to Identify Patients with Left Ventricular Systolic Dysfunction Presenting to the Emergency Department with Dyspnea: 

The AUC, accuracy, sensitivity, and specificity were 0.85 (95% CI: 0.83 - 0.88), 86%, 63%, and 91%, respectively.

Esophageal Endoscopy After Catheter Ablation of Atrial Fibrillation Using Ablation-Index Guided High-Power

Targeted Left Ventricular Lead Implantation Strategy for Non-Left Bundle Branch Block Patients

Worse Prognosis in Brugada Syndrome Patients with Arrhythmogenic Cardiomyopathy Features: The right ventricular outflow tract dilation criterion improved detection of arrhythmic BrS patients.

Cardiology:

Cost-effectiveness of Sacubitril-Valsartan in Hospitalized Patients Who Have Heart Failure with Reduced Ejection Fraction

Built Environment Approaches to Increase Physical Activity: A Science Advisory from the American Heart Association

Long-Term Adverse Cardiac Outcomes in Patients with Sarcoidosis

Optimum Blood Pressure in Patients with Shock After Acute Myocardial Infarction and Cardiac Arrest

Heart Failure with Recovered Left Ventricular Ejection Fraction

JACC Scientific Expert Panel

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis

JACC Review Topic of the Week

Transvalvular Ventricular Unloading Before Reperfusion in Acute Myocardial Infarction

Electrophysiology:

Cardiac radioablation—A systematic review

Leadless pacemakers reduce risk of device-related infection: Review of the potential mechanisms

How to use intracardiac echocardiography to guide catheter ablation of outflow tract ventricular arrhythmias

Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate–activated protein kinase

Presentation and Outcome of Arrhythmic Mitral Valve Prolapse 

Complete Electroanatomic Imaging of the Diastolic Pathway is Associated with Improved Freedom from Ventricular Tachycardia Recurrence

Subcutaneous or Transvenous Defibrillator Therapy

Cardiology:

Evaluation of Stress Cardiac Magnetic Resonance Imaging in Risk Reclassification of Patients with Suspected Coronary Artery Disease

Randomized Trials Versus Common Sense and Clinical Observation

JACC Review Topic of the Week

Targeting RNA With Antisense Oligonucleotides and Small Interfering RNA

JACC State-of-the-Art Review

2020 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants

Effect of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients with HFpEF

Transcatheter Valve-in-Valve Aortic Valve Replacement as an Alternative to Surgical Re-Replacement

Penetrance of Hypertrophic Cardiomyopathy in Sarcomere Protein Mutation Carriers

Electrophysiology:

Sex-specific efficacy and safety of cryoballoon versus radiofrequency ablation for atrial fibrillation: An individual patient data meta-analysis

Stereotactic arrhythmia radioablation for refractory scar-related ventricular tachycardia

Novel risk calculator performance in athletes with arrhythmogenic right ventricular cardiomyopathy

Periaortic ventricular tachycardia in structural heart disease: Evidence of localized reentrant mechanisms

Usefulness of positive T wave in lead aVR in predicting arrhythmic events and mortality in patients with hypertrophic cardiomyopathy

Atrial tachycardia eliminated at the ventricular side in patients with congenitally corrected transposition of the great arteries: Electrophysiological findings and anatomical concerns

Cardiology:

Association of Low-Dose Triple Combination Therapy with Therapeutic Inertia and Prescribing Patterns in Patients with Hypertension: A Secondary Analysis of the TRIUMPH Trial

Association of Natriuretic Peptide Levels After Transcatheter Aortic Valve Replacement with Subsequent Clinical Outcomes

Pathogenic Autoimmunity in Atherosclerosis Evolves from Initially Protective ApoB-Reactive CD4+ T-Regulatory Cells

The Expected 30-year Benefits of Early Versus Delayed Primary Prevention of Cardiovascular Disease by Lipid Lowering

Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma

Electrophysiology:

Comparison of Atrial Remodeling Caused by Sustained Atrial Flutter Versus Atrial Fibrillation

Long-Term Outcomes of Implantable Cardioverter-Defibrillator Therapy in the SCD-HeFT

Inhibition of Human Ether-A-Go-Go-Related Gene (hERG) Potassium Current by the Novel Sotalol Analogue, Soestalol

Frequency Content of Unipolar Electrograms May Predict Deep Intramural Excitable Substrate

Acute Hemoptysis Following Cryoballoon Pulmonary Vein Isolation

High-Density Characterization of the Ventricular Electrical Substrate During Sinus Rhythm in Post–Myocardial Infarction Patients

Characterization of Complex Atrial Tachycardia in Patients with Previous Atrial Interventions Using High-Resolution Mapping

Cardiac Resynchronization Therapy in Patients with Nonischemic Cardiomyopathy Using Left Bundle Branch Pacing

Electrocardiographic Analysis for His Bundle Pacing at Implantation and Follow-Up

Electrophysiology:

Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers

Subclinical atherosclerosis is associated with incident atrial fibrillation: a systematic review and meta-analysis

Advanced interatrial block and P-wave duration are associated with atrial fibrillation and stroke in older adults with heart disease: the BAYES registry

Correlation of magnetic resonance imaging and post-ablation endoscopy to detect oesophageal thermal injury in patients after atrial fibrillation ablation: MRI-EDEL-study

Is Atrial Fibrillation Noninducibility by Burst Pacing After Catheter Ablation Associated with Reduced Clinical Recurrence? A Systematic Review and Meta‐Analysis

Cardiology:

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data

The High, the Low, and the Narrow QRS in Peripartum Cardiomyopathy

Serial Innovation to Bring Transformative Precision Medicines to People with Serious Diseases

Precision Health Analytics with Predictive Analytics and Implementation Research

The Hybrid Coronary Approach for Optimal Revascularization

JACC Review Topic of the Week

Effect of C-Reactive Protein on Lipoprotein(a)-Associated Cardiovascular Risk in Optimally Treated Patients with High-Risk Vascular Disease

Natural History of Asymptomatic Severe Aortic Stenosis and the Association of Early Intervention with Outcomes

Cardiology:

Impact of Left Atrial Appendage Exclusion on Short-Term Outcomes in Isolated Coronary Artery Bypass Graft Surgery

Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2)

Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism

Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice

Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype

Electrophysiology:

Electrocardiogram Standards for Children and Young Adults Using Z-scores

Endocardial-Epicardial Phase Mapping of Prolonged Persistent Atrial Fibrillation Recordings: High Prevalence of Dissociated Activation Patterns

Machine Learning to Classify Intracardiac Electrical Patterns during Atrial Fibrillation

Relationship Between Fractionated Signal Areas in the Atrial Muscle During Sinus Rhythm and Atrial Pacing and Non-pulmonary Vein Foci: A Novel Mapping Strategy

Electrophysiology and Cardiology:

New Electrocardiographic Algorithm for the Diagnosis of Acute Myocardial Infarction in Patients with Left Bundle Branch Block

Exposure to Air Pollution and Particle Radioactivity with the Risk of Ventricular Arrhythmias

Gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration

Carotid Atherosclerosis Evolution when Targeting a Low-Density Lipoprotein Cholesterol Concentration < 70 mg/dL after an Ischemic Stroke of Atherosclerotic Origin

COVID-19 and Disruptive Modifications to Cardiac Critical Care Delivery

JACC Review Topic of the Week

Baroreflex Activation Therapy in Patients With Heart Failure With Reduced Ejection Fraction

Smartphone Activation of Citizen Responders to Facilitate Defibrillation in Out-of-Hospital Cardiac Arrest

Hypertensive coronary microvascular dysfunction: a subclinical marker of end organ damage and heart failure

A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair

Electrophysiology:

Cryoballoon Ablation of Pulmonary Veins for Persistent Atrial Fibrillation: Results from the Multicenter STOP Persistent AF Trial

Predictors of adverse outcome in patients with frequent premature ventricular complexes: The ABC-VT risk score

Outcomes of catheter ablation of ventricular arrhythmia originating from the left ventricular summit: A multicenter study

Programming implantable cardioverter–defibrillator in primary prevention: Guideline concordance and outcomes.

Intentional nontherapy in long QT syndrome

Ablation strategies for intramural ventricular arrhythmias

Cryoballoon ablation dosing: From the bench to the bedside and back

Choosing ICD for patients with hypertrophic cardiomyopathy:

Appropriate and inappropriate shocks in hypertrophic cardiomyopathy patients with subcutaneous implantable cardioverter-defibrillators: An international multicenter study

Antitachycardia pacing for shock prevention in patients with hypertrophic cardiomyopathy and ventricular tachycardia

A Lattice-Tip Temperature-Controlled Radiofrequency Ablation Catheter

Durability of Pulmonary Vein Isolation and Linear Lesion Block

Artificial Intelligence 

The European artificial intelligence strategy: implications and challenges for digital health

A deep learning algorithm to detect anaemia with ECGs: a retrospective, multicentre study

Automatic multilabel electrocardiogram diagnosis of heart rhythm or conduction abnormalities with deep learning: a cohort study

Deep learning using electrocardiographs

A deep neural network trained to interpret results from electrocardiograms: better than physicians?

Electrophysiology:

Recurrence of Atrial Fibrillation After Catheter Ablation or Antiarrhythmic Drug Therapy in the CABANA Trial

Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients with Atrial Fibrillation

Additional Low‐Voltage‐Area Ablation in Patients with Paroxysmal Atrial Fibrillation: Results of the Randomized Controlled VOLCANO Trial

Duration of Inducible Ventricular Tachycardia Early After ST‐Segment–Elevation Myocardial Infarction and Its Impact on Mortality and Ventricular Tachycardia Recurrence

Cardiology:

Routine Revascularization versus Initial Medical Therapy for Stable Ischemic Heart Disease: A Systematic Review and Meta-Analysis of Randomized Trials